Abstract
Sialoadhesin (Sn, also known as siglec-1 and CD169) is a macrophage-restricted, cell surface receptor that is conserved across mammals. Sn is a member of the sialic acid-binding IgG-like lectin (Siglec) family of proteins characterised by affinity to specifically sialylated ligands, and under normal conditions is expressed on subsets of macrophages in secondary lymphoid tissues, such as lymph node and spleen. However, Sn positive macrophages (Mφ) can also be found in a variety of pathological conditions, including (autoimmune) inflammatory infiltrates and tumours. Sn has been shown to contribute to sialylated pathogen uptake, antigen presentation, lymphocyte proliferation and influence both immunity and tolerance. This review presents Sn as a Mφ-specific marker of inflammation and immunoregulation with the potential of becoming an important biomarker for immunologically active Mφ and target for therapy. © 2012 The Authors. Immunology © 2012 Blackwell Publishing Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 198-207 |
| Number of pages | 10 |
| Journal | Immunology |
| Volume | 138 |
| Issue number | 3 |
| Early online date | 5 Feb 2013 |
| DOIs | |
| Publication status | Published - Mar 2013 |