Silica passivated conjugated polymer nanoparticles for biological imaging applications

Struan Bourke, Laura Urbano, Antoni Olona, Ferran Valderrama, Lea Ann Dailey, Mark A. Green

Research output: Chapter in Book/Report/Conference proceedingOther chapter contributionpeer-review

2 Citations (Scopus)
172 Downloads (Pure)

Abstract

Colorectal and prostate cancers are major causes of cancer-related death, with early detection key to increased survival. However, as symptoms occur during advanced stages and current diagnostic methods have limitations, there is a need for new fluorescent probes that remain bright, are biocompatible and can be targeted. Conjugated polymer nanoparticles have shown great promise in biological imaging due to their unique optical properties. We have synthesised small, bright, photo-stable CN-PPV, nanoparticles encapsulated with poloxamer polymer and a thin silica shell. By incubating the CN-PPV silica shelled cross-linked (SSCL) nanoparticles in mammalian (HeLa) cells; we were able to show that cellular uptake occurred. Uptake was also shown by incubating the nanoparticles in RWPE1, WPE1-NB26 and WPE1- NA22 prostate cancer cell lines. Finally, HEK cells were used to show the particles had limited cytotoxicity.

Original languageEnglish
Title of host publicationReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX
PublisherSPIE
Volume10079
ISBN (Electronic)9781510605992
DOIs
Publication statusPublished - 21 Feb 2017
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX 2017 - San Francisco, United States
Duration: 30 Jan 201731 Jan 2017

Conference

ConferenceReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX 2017
Country/TerritoryUnited States
CitySan Francisco
Period30/01/201731/01/2017

Keywords

  • Biological imaging
  • Cancer imaging
  • Conjugated polymers
  • Nanoparticles
  • Silica shells

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