TY - JOUR
T1 - Silicone rubber encapsulation for an endoscopically implantable gastrostimulator
AU - Lonys, Laurent
AU - Vanhoestenberghe, Anne
AU - Julémont, Nicolas
AU - Godet, Stéphane
AU - Delplancke, Marie Paule
AU - Mathys, Pierre
AU - Nonclercq, Antoine
N1 - Publisher Copyright:
© 2015, International Federation for Medical and Biological Engineering.
PY - 2015/3/13
Y1 - 2015/3/13
N2 - Gastrointestinal stimulator implants have recently shown positive results in treating obesity. However, the implantation currently requires an invasive surgical procedure. Endoscopy could be used to place the gastric stimulator in the stomach, hence avoiding the riskier surgery. The implant then needs to go through the oesophagus and be located inside the stomach, which imposes new design constraints, such as miniaturization and protecting the electronic circuit against the highly acidic environment of the stomach. We propose to protect the implant by encapsulation with silicone rubber. This paper lists the advantages of this method compared to the more usual approach of a hermetic enclosure and then presents a method to evaluate the underwater adhesive stability of six adhesive/substrate couples, using repeated lap-shear tests and an elevated temperature to accelerate the ageing process. The results for different adhesive/substrate couples tested, presented on probability plots, show that FR4 and alumina substrates with MED4-4220 silicone rubber are suitable for a first implantable prototype. We then compare these with the predicted lifetimes of bonds between historical standard silicone rubber DC3140 and different substrates and describe the encapsulation of our gastrostimulator.
AB - Gastrointestinal stimulator implants have recently shown positive results in treating obesity. However, the implantation currently requires an invasive surgical procedure. Endoscopy could be used to place the gastric stimulator in the stomach, hence avoiding the riskier surgery. The implant then needs to go through the oesophagus and be located inside the stomach, which imposes new design constraints, such as miniaturization and protecting the electronic circuit against the highly acidic environment of the stomach. We propose to protect the implant by encapsulation with silicone rubber. This paper lists the advantages of this method compared to the more usual approach of a hermetic enclosure and then presents a method to evaluate the underwater adhesive stability of six adhesive/substrate couples, using repeated lap-shear tests and an elevated temperature to accelerate the ageing process. The results for different adhesive/substrate couples tested, presented on probability plots, show that FR4 and alumina substrates with MED4-4220 silicone rubber are suitable for a first implantable prototype. We then compare these with the predicted lifetimes of bonds between historical standard silicone rubber DC3140 and different substrates and describe the encapsulation of our gastrostimulator.
KW - Accelerated testing
KW - Encapsulation
KW - Endoscopic implantation
KW - Gastric electrical stimulation
KW - Lap-shear test
KW - Obesity
KW - Packaging
KW - Silicone rubber
UR - http://www.scopus.com/inward/record.url?scp=84925497362&partnerID=8YFLogxK
U2 - 10.1007/s11517-014-1236-9
DO - 10.1007/s11517-014-1236-9
M3 - Article
C2 - 25559120
AN - SCOPUS:84925497362
SN - 0140-0118
VL - 53
SP - 319
EP - 329
JO - Medical and Biological Engineering and Computing
JF - Medical and Biological Engineering and Computing
IS - 4
ER -