Similarities between borderline personality disorder and post traumatic stress disorder: Evidence from resting-state meta-analysis

Ali Amad*, Joaquim Radua, Guillaume Vaiva, Steve CR Williams, Thomas Fovet

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

Borderline personality disorder (BPD) and post-traumatic stress disorder (PTSD) are common psychiatric disorders. The nature of the relationship between BPD and PTSD remains controversial, but it has been suggested that these disorders should brought closer because of their many similarities. We thus performed a quantitative meta-analysis of resting-state functional imaging to assess similarities in the brain activation across BPD and PTSD diagnostic groups. Overlap analyses revealed decreased activation in the left and right precuneus of both BPD and PTSD groups when compared to control subjects. BPD showed significant increased, but PTSD showed decreased activation, relative to control subjects, in the anterior cingulate/paracingulate gyri and in the left superior frontal gyrus. Complementary overlap analyses on a subgroup of studies with similar sex and age distribution partially confirmed the main results as the same pattern of functional activation in the anterior cingulate and in the left superior frontal gyrus were found. Our findings are in agreement with the hypothesis that BPD and PTSD share common neuropathological pathways.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalNeuroscience and Biobehavioral Reviews
Volume105
Early online date29 Jul 2019
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Age-dependant neuroplasticity
  • Borderline personality disorder
  • Post-traumatic stress disorder
  • Resting state
  • Trauma

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