Simulating Ventricular Systolic Motion in a Four-chamber Heart Model with Spatially Varying Robin Boundary Conditions to Model the Effect of the Pericardium

Marina Strocchi; Matthias A. F.  Gsell; Christoph M.  Augustin; Orod Razeghi; Caroline Helen Roney; A. J. Prassl; Edward Vigmond; Jonathan Behar; Justin Gould; Christopher A. Rinaldi; Martin J. Bishop; Gernot Planck; Steven Alexander Niederer

doi:10.1016/j.jbiomech.2020.109645

Simulating Ventricular Systolic Motion in a Four-chamber Heart Model with Spatially Varying Robin Boundary Conditions to Model the Effect of the Pericardium

Marina Strocchi, Matthias A. F. Gsell, Christoph M. Augustin, Orod Razeghi, Caroline Helen Roney, A. J. Prassl, Edward Vigmond, Jonathan Behar, Justin Gould, Christopher A. Rinaldi, Martin J. Bishop, Gernot Planck, Steven Alexander Niederer

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63 Citations (Scopus)

Abstract

The pericardium affects cardiac motion by limiting epicardial displacement normal to the surface. In computational studies, it is important for the model to replicate realistic motion, as this affects the physiological fidelity of the model. Previous computational studies showed that accounting for the effect of the pericardium allows for a more realistic motion simulation. In this study, we describe the mechanism through which the pericardium causes improved cardiac motion. We simulated electrical activation and contraction of the ventricles on a four-chamber heart in the presence and absence of the effect of the pericardium. We simulated the mechanical constraints imposed by the pericardium by applying normal Robin boundary conditions on the ventricular epicardium. We defined a regional scaling of normal springs stiffness based on image-derived motion from CT images. The presence of the pericardium reduced the error between simulated and image-derived end-systolic configurations from 12.8±4.1mm to 5.7±2.5mm. First, the pericardium prevents the ventricles from spherising during isovolumic contraction, reducing the outward motion of the free walls normal to the surface and the upwards motion of the apex. Second, by restricting the inward motion of the ventricle free and apical walls the pericardium increases atrioventricular plane displacement by four folds during ejection. Our results provide a mechanistic explanation of the importance of the pericardium in physiological simulations of electromechanical cardiac function.

Original language	English
Journal	Journal of Biomechanics
DOIs	https://doi.org/10.1016/j.jbiomech.2020.109645
Publication status	Accepted/In press - 16 Jan 2020

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Strocchi, M., Gsell, M. A. F., Augustin, C. M., Razeghi, O., Roney, C. H., Prassl, A. J., Vigmond, E., Behar, J., Gould, J., Rinaldi, C. A., Bishop, M. J., Planck, G., & Niederer, S. A. (Accepted/In press). Simulating Ventricular Systolic Motion in a Four-chamber Heart Model with Spatially Varying Robin Boundary Conditions to Model the Effect of the Pericardium. Journal of Biomechanics. https://doi.org/10.1016/j.jbiomech.2020.109645

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title = "Simulating Ventricular Systolic Motion in a Four-chamber Heart Model with Spatially Varying Robin Boundary Conditions to Model the Effect of the Pericardium",

abstract = "The pericardium affects cardiac motion by limiting epicardial displacement normal to the surface. In computational studies, it is important for the model to replicate realistic motion, as this affects the physiological fidelity of the model. Previous computational studies showed that accounting for the effect of the pericardium allows for a more realistic motion simulation. In this study, we describe the mechanism through which the pericardium causes improved cardiac motion. We simulated electrical activation and contraction of the ventricles on a four-chamber heart in the presence and absence of the effect of the pericardium. We simulated the mechanical constraints imposed by the pericardium by applying normal Robin boundary conditions on the ventricular epicardium. We defined a regional scaling of normal springs stiffness based on image-derived motion from CT images. The presence of the pericardium reduced the error between simulated and image-derived end-systolic configurations from 12.8±4.1mm to 5.7±2.5mm. First, the pericardium prevents the ventricles from spherising during isovolumic contraction, reducing the outward motion of the free walls normal to the surface and the upwards motion of the apex. Second, by restricting the inward motion of the ventricle free and apical walls the pericardium increases atrioventricular plane displacement by four folds during ejection. Our results provide a mechanistic explanation of the importance of the pericardium in physiological simulations of electromechanical cardiac function.",

author = "Marina Strocchi and Gsell, {Matthias A. F.} and Augustin, {Christoph M.} and Orod Razeghi and Roney, {Caroline Helen} and Prassl, {A. J.} and Edward Vigmond and Jonathan Behar and Justin Gould and Rinaldi, {Christopher A.} and Bishop, {Martin J.} and Gernot Planck and Niederer, {Steven Alexander}",

year = "2020",

month = jan,

day = "16",

doi = "10.1016/j.jbiomech.2020.109645",

language = "English",

journal = "Journal of Biomechanics",

issn = "0021-9290",

publisher = "Elsevier Limited",

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Strocchi, M, Gsell, MAF, Augustin, CM, Razeghi, O , Roney, CH, Prassl, AJ, Vigmond, E, Behar, J, Gould, J, Rinaldi, CA, Bishop, MJ, Planck, G & Niederer, SA 2020, 'Simulating Ventricular Systolic Motion in a Four-chamber Heart Model with Spatially Varying Robin Boundary Conditions to Model the Effect of the Pericardium', Journal of Biomechanics. https://doi.org/10.1016/j.jbiomech.2020.109645

TY - JOUR

T1 - Simulating Ventricular Systolic Motion in a Four-chamber Heart Model with Spatially Varying Robin Boundary Conditions to Model the Effect of the Pericardium

AU - Strocchi, Marina

AU - Gsell, Matthias A. F.

AU - Augustin, Christoph M.

AU - Razeghi, Orod

AU - Roney, Caroline Helen

AU - Prassl, A. J.

AU - Vigmond, Edward

AU - Behar, Jonathan

AU - Gould, Justin

AU - Rinaldi, Christopher A.

AU - Bishop, Martin J.

AU - Planck, Gernot

AU - Niederer, Steven Alexander

PY - 2020/1/16

Y1 - 2020/1/16

N2 - The pericardium affects cardiac motion by limiting epicardial displacement normal to the surface. In computational studies, it is important for the model to replicate realistic motion, as this affects the physiological fidelity of the model. Previous computational studies showed that accounting for the effect of the pericardium allows for a more realistic motion simulation. In this study, we describe the mechanism through which the pericardium causes improved cardiac motion. We simulated electrical activation and contraction of the ventricles on a four-chamber heart in the presence and absence of the effect of the pericardium. We simulated the mechanical constraints imposed by the pericardium by applying normal Robin boundary conditions on the ventricular epicardium. We defined a regional scaling of normal springs stiffness based on image-derived motion from CT images. The presence of the pericardium reduced the error between simulated and image-derived end-systolic configurations from 12.8±4.1mm to 5.7±2.5mm. First, the pericardium prevents the ventricles from spherising during isovolumic contraction, reducing the outward motion of the free walls normal to the surface and the upwards motion of the apex. Second, by restricting the inward motion of the ventricle free and apical walls the pericardium increases atrioventricular plane displacement by four folds during ejection. Our results provide a mechanistic explanation of the importance of the pericardium in physiological simulations of electromechanical cardiac function.

AB - The pericardium affects cardiac motion by limiting epicardial displacement normal to the surface. In computational studies, it is important for the model to replicate realistic motion, as this affects the physiological fidelity of the model. Previous computational studies showed that accounting for the effect of the pericardium allows for a more realistic motion simulation. In this study, we describe the mechanism through which the pericardium causes improved cardiac motion. We simulated electrical activation and contraction of the ventricles on a four-chamber heart in the presence and absence of the effect of the pericardium. We simulated the mechanical constraints imposed by the pericardium by applying normal Robin boundary conditions on the ventricular epicardium. We defined a regional scaling of normal springs stiffness based on image-derived motion from CT images. The presence of the pericardium reduced the error between simulated and image-derived end-systolic configurations from 12.8±4.1mm to 5.7±2.5mm. First, the pericardium prevents the ventricles from spherising during isovolumic contraction, reducing the outward motion of the free walls normal to the surface and the upwards motion of the apex. Second, by restricting the inward motion of the ventricle free and apical walls the pericardium increases atrioventricular plane displacement by four folds during ejection. Our results provide a mechanistic explanation of the importance of the pericardium in physiological simulations of electromechanical cardiac function.

U2 - 10.1016/j.jbiomech.2020.109645

DO - 10.1016/j.jbiomech.2020.109645

M3 - Article

SN - 0021-9290

JO - Journal of Biomechanics

JF - Journal of Biomechanics

ER -

Simulating Ventricular Systolic Motion in a Four-chamber Heart Model with Spatially Varying Robin Boundary Conditions to Model the Effect of the Pericardium

Abstract

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