Simulation of local and global atrophy in Alzheimer's disease studies

Oscar Camara-Rey, Martin Schweiger, Rachael I. Scahill, William R. Crum, Julia A. Schnabel, Derek L. G. Hill, Nick C. Fox

Research output: Chapter in Book/Report/Conference proceedingConference paper

4 Citations (Scopus)

Abstract

We propose a method for atrophy simulation in structural MR images based on finite-element methods, providing data for objective evaluation of atrophy measurement techniques. The modelling of diffuse global and regional atrophy is based on volumetric measurements from patients with known disease and guided by clinical knowledge of the relative pathological involvement of regions. The consequent biomechanical readjustment of structures is modelled using conventional physics-based techniques based on tissue properties and simulating plausible deformations with finite-element methods. Tissue characterization is performed by means of the meshing of a labelled brain atlas, creating a reference volumetric mesh, and a partial volume tissue model is used to reduce the impact of the mesh discretization. An example of simulated data is shown and a visual evaluation protocol used by experts has been developed to assess the degree of realism of the simulated images. First results demonstrate the potential of the proposed methodology.

Original languageEnglish
Title of host publicationMEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2
EditorsR Larsen, M Nielsen, J Sporring
Place of PublicationBERLIN
PublisherSpringer
Pages937-945
Number of pages9
ISBN (Print)3-540-44727-X
Publication statusPublished - 2006
Event9th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006) - Copenhagen
Duration: 1 Oct 20066 Oct 2006

Conference

Conference9th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006)
CityCopenhagen
Period1/10/20066/10/2006

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