TY - JOUR
T1 - Simultaneous 3D T1, T2, and fat-signal-fraction mapping with respiratory-motion correction for comprehensive liver tissue characterization at 0.55 T
AU - Tripp, Donovan P.
AU - Kunze, Karl P.
AU - Crabb, Michael G.
AU - Prieto, Claudia
AU - Neji, Radhouene
AU - Botnar, René M.
N1 - Publisher Copyright:
© 2024 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
PY - 2024/12
Y1 - 2024/12
N2 - Purpose: To develop a framework for simultaneous three-dimensional (3D) mapping of (Formula presented.), (Formula presented.), and fat signal fraction in the liver at 0.55 T. Methods: The proposed sequence acquires four interleaved 3D volumes with a two-echo Dixon readout. (Formula presented.) and (Formula presented.) are encoded into each volume via preparation modules, and dictionary matching allows simultaneous estimation of (Formula presented.), (Formula presented.), and (Formula presented.) for water and fat separately. 2D image navigators permit respiratory binning, and motion fields from nonrigid registration between bins are used in a nonrigid respiratory-motion-corrected reconstruction, enabling 100% scan efficiency from a free-breathing acquisition. The integrated nature of the framework ensures the resulting maps are always co-registered. Results: (Formula presented.), (Formula presented.), and fat-signal-fraction measurements in phantoms correlated strongly (adjusted (Formula presented.)) with reference measurements. Mean liver tissue parameter values in 10 healthy volunteers were (Formula presented.), (Formula presented.), and (Formula presented.) for (Formula presented.), (Formula presented.), and fat signal fraction, giving biases of (Formula presented.), (Formula presented.), and (Formula presented.) percentage points, respectively, when compared to conventional methods. Conclusion: A novel sequence for comprehensive characterization of liver tissue at 0.55 T was developed. The sequence provides co-registered 3D (Formula presented.), (Formula presented.), and fat-signal-fraction maps with full coverage of the liver, from a single nine-and-a-half-minute free-breathing scan. Further development is needed to achieve accurate proton-density fat fraction (PDFF) estimation in vivo.
AB - Purpose: To develop a framework for simultaneous three-dimensional (3D) mapping of (Formula presented.), (Formula presented.), and fat signal fraction in the liver at 0.55 T. Methods: The proposed sequence acquires four interleaved 3D volumes with a two-echo Dixon readout. (Formula presented.) and (Formula presented.) are encoded into each volume via preparation modules, and dictionary matching allows simultaneous estimation of (Formula presented.), (Formula presented.), and (Formula presented.) for water and fat separately. 2D image navigators permit respiratory binning, and motion fields from nonrigid registration between bins are used in a nonrigid respiratory-motion-corrected reconstruction, enabling 100% scan efficiency from a free-breathing acquisition. The integrated nature of the framework ensures the resulting maps are always co-registered. Results: (Formula presented.), (Formula presented.), and fat-signal-fraction measurements in phantoms correlated strongly (adjusted (Formula presented.)) with reference measurements. Mean liver tissue parameter values in 10 healthy volunteers were (Formula presented.), (Formula presented.), and (Formula presented.) for (Formula presented.), (Formula presented.), and fat signal fraction, giving biases of (Formula presented.), (Formula presented.), and (Formula presented.) percentage points, respectively, when compared to conventional methods. Conclusion: A novel sequence for comprehensive characterization of liver tissue at 0.55 T was developed. The sequence provides co-registered 3D (Formula presented.), (Formula presented.), and fat-signal-fraction maps with full coverage of the liver, from a single nine-and-a-half-minute free-breathing scan. Further development is needed to achieve accurate proton-density fat fraction (PDFF) estimation in vivo.
KW - liver
KW - low-field MR
KW - motion correction
KW - NAFLD
KW - quantitative imaging
UR - http://www.scopus.com/inward/record.url?scp=85200007202&partnerID=8YFLogxK
U2 - 10.1002/mrm.30236
DO - 10.1002/mrm.30236
M3 - Article
C2 - 39075868
AN - SCOPUS:85200007202
SN - 0740-3194
VL - 92
SP - 2433
EP - 2446
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 6
ER -
