Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T2 prep-IR

TY - JOUR

T1 - Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T2 prep-IR

AU - Milotta, Giorgia

AU - Ginami, Giulia

AU - Lima da Cruz, Gastao Jose

AU - Neji, Radhouene

AU - Prieto Vasquez, Claudia

AU - Botnar, Rene Michael

N1 - © 2019 International Society for Magnetic Resonance in Medicine.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - PURPOSE: To develop a motion-corrected 3D flow-insensitive imaging approach interleaved T2 prepared-inversion recovery (iT2 prep-IR) for simultaneous lumen and wall visualization of the great thoracic vessels and cardiac structures.METHODS: A 3D flow-insensitive approach for simultaneous cardiovascular lumen and wall visualization (iT2 prep) has been previously proposed. This approach requires subject-dependent weighted subtraction to completely null the arterial blood signal in the black-blood volume. Here, we propose an (T2 prep-IR) approach to improve wall visualization and remove need for weighted subtraction. The proposed sequence is based on the acquisition and direct subtraction of 2 interleaved 3D whole-heart data sets acquired with and without T2 prep-IR preparation. Image navigators are acquired before data acquisition to enable 2D translational and 3D non-rigid motion correction allowing 100% respiratory scan efficiency. The proposed approach was evaluated in 10 healthy subjects and compared with the conventional 2D double inversion recovery (DIR) sequence and the 3D iT2 prep sequence. Additionally, 5 patients with congenital heart disease were acquired to test the clinical feasibility of the proposed approach.RESULTS: The proposed iT2 prep-IR sequence showed improved blood nulling compared to both DIR and iT2 prep techniques in terms of SNR (SNRblood = 6.9, 12.2, and 18.2, respectively) and contrast-to-noise-ratio (CNRmyoc-blood = 28.4, 15.4, and 15.3, respectively). No statistical difference was observed between iT2 prep-IR, iT2 prep and DIR atrial and ventricular wall thickness quantification.CONCLUSION: The proposed interleaved T2 prep-IR sequence enables the simultaneous lumen and wall visualization of cardiac structures and shows promising results in terms of SNR, CNR, and wall thickness measurement.

AB - PURPOSE: To develop a motion-corrected 3D flow-insensitive imaging approach interleaved T2 prepared-inversion recovery (iT2 prep-IR) for simultaneous lumen and wall visualization of the great thoracic vessels and cardiac structures.METHODS: A 3D flow-insensitive approach for simultaneous cardiovascular lumen and wall visualization (iT2 prep) has been previously proposed. This approach requires subject-dependent weighted subtraction to completely null the arterial blood signal in the black-blood volume. Here, we propose an (T2 prep-IR) approach to improve wall visualization and remove need for weighted subtraction. The proposed sequence is based on the acquisition and direct subtraction of 2 interleaved 3D whole-heart data sets acquired with and without T2 prep-IR preparation. Image navigators are acquired before data acquisition to enable 2D translational and 3D non-rigid motion correction allowing 100% respiratory scan efficiency. The proposed approach was evaluated in 10 healthy subjects and compared with the conventional 2D double inversion recovery (DIR) sequence and the 3D iT2 prep sequence. Additionally, 5 patients with congenital heart disease were acquired to test the clinical feasibility of the proposed approach.RESULTS: The proposed iT2 prep-IR sequence showed improved blood nulling compared to both DIR and iT2 prep techniques in terms of SNR (SNRblood = 6.9, 12.2, and 18.2, respectively) and contrast-to-noise-ratio (CNRmyoc-blood = 28.4, 15.4, and 15.3, respectively). No statistical difference was observed between iT2 prep-IR, iT2 prep and DIR atrial and ventricular wall thickness quantification.CONCLUSION: The proposed interleaved T2 prep-IR sequence enables the simultaneous lumen and wall visualization of cardiac structures and shows promising results in terms of SNR, CNR, and wall thickness measurement.

KW - 3D whole-heart

KW - black-blood atrial wall

KW - black-blood vessel wall

KW - bright-blood cardiac anatomy

KW - interleaved T prep-IR

KW - respiratory motion correction

UR - http://www.scopus.com/inward/record.url?scp=85063301559&partnerID=8YFLogxK

U2 - 10.1002/mrm.27734

DO - 10.1002/mrm.27734

M3 - Article

C2 - 30896049

SN - 0740-3194

VL - 82

SP - 312

EP - 325

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 1

M1 - MRM-18-19461.R2

ER -