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Single molecules can operate as primitive biological sensors, switches and oscillators

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Single molecules can operate as primitive biological sensors, switches and oscillators. / Hernansaiz-Ballesteros, Rosa D.; Cardelli, Luca; Csikász-Nagy, Attila.

In: Bmc Systems Biology, Vol. 12, No. 1, 70, 18.06.2018.

Research output: Contribution to journalArticle

Harvard

Hernansaiz-Ballesteros, RD, Cardelli, L & Csikász-Nagy, A 2018, 'Single molecules can operate as primitive biological sensors, switches and oscillators', Bmc Systems Biology, vol. 12, no. 1, 70. https://doi.org/10.1186/s12918-018-0596-4

APA

Hernansaiz-Ballesteros, R. D., Cardelli, L., & Csikász-Nagy, A. (2018). Single molecules can operate as primitive biological sensors, switches and oscillators. Bmc Systems Biology, 12(1), [70]. https://doi.org/10.1186/s12918-018-0596-4

Vancouver

Hernansaiz-Ballesteros RD, Cardelli L, Csikász-Nagy A. Single molecules can operate as primitive biological sensors, switches and oscillators. Bmc Systems Biology. 2018 Jun 18;12(1). 70. https://doi.org/10.1186/s12918-018-0596-4

Author

Hernansaiz-Ballesteros, Rosa D. ; Cardelli, Luca ; Csikász-Nagy, Attila. / Single molecules can operate as primitive biological sensors, switches and oscillators. In: Bmc Systems Biology. 2018 ; Vol. 12, No. 1.

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@article{81cca435bfb44d10b804fb35c7e12356,
title = "Single molecules can operate as primitive biological sensors, switches and oscillators",
abstract = "Background: Switch-like and oscillatory dynamical systems are widely observed in biology. We investigate the simplest biological switch that is composed of a single molecule that can be autocatalytically converted between two opposing activity forms. We test how this simple network can keep its switching behaviour under perturbations in the system. Results: We show that this molecule can work as a robust bistable system, even for alterations in the reactions that drive the switching between various conformations. We propose that this single molecule system could work as a primitive biological sensor and show by steady state analysis of a mathematical model of the system that it could switch between possible states for changes in environmental signals. Particularly, we show that a single molecule phosphorylation-dephosphorylation switch could work as a nucleotide or energy sensor. We also notice that a given set of reductions in the reaction network can lead to the emergence of oscillatory behaviour. Conclusions: We propose that evolution could have converted this switch into a single molecule oscillator, which could have been used as a primitive timekeeper. We discuss how the structure of the simplest known circadian clock regulatory system, found in cyanobacteria, resembles the proposed single molecule oscillator. Besides, we speculate if such minimal systems could have existed in an RNA world.",
keywords = "Approximate majority, Bistability, Circadian rhythm, Computational biology, Evolution, Mathematical modelling, Multistability, Networks, Oscillation, RNA world",
author = "Hernansaiz-Ballesteros, {Rosa D.} and Luca Cardelli and Attila Csik{\'a}sz-Nagy",
year = "2018",
month = jun,
day = "18",
doi = "10.1186/s12918-018-0596-4",
language = "English",
volume = "12",
journal = "Bmc Systems Biology",
issn = "1752-0509",
publisher = "BioMed Central",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Single molecules can operate as primitive biological sensors, switches and oscillators

AU - Hernansaiz-Ballesteros, Rosa D.

AU - Cardelli, Luca

AU - Csikász-Nagy, Attila

PY - 2018/6/18

Y1 - 2018/6/18

N2 - Background: Switch-like and oscillatory dynamical systems are widely observed in biology. We investigate the simplest biological switch that is composed of a single molecule that can be autocatalytically converted between two opposing activity forms. We test how this simple network can keep its switching behaviour under perturbations in the system. Results: We show that this molecule can work as a robust bistable system, even for alterations in the reactions that drive the switching between various conformations. We propose that this single molecule system could work as a primitive biological sensor and show by steady state analysis of a mathematical model of the system that it could switch between possible states for changes in environmental signals. Particularly, we show that a single molecule phosphorylation-dephosphorylation switch could work as a nucleotide or energy sensor. We also notice that a given set of reductions in the reaction network can lead to the emergence of oscillatory behaviour. Conclusions: We propose that evolution could have converted this switch into a single molecule oscillator, which could have been used as a primitive timekeeper. We discuss how the structure of the simplest known circadian clock regulatory system, found in cyanobacteria, resembles the proposed single molecule oscillator. Besides, we speculate if such minimal systems could have existed in an RNA world.

AB - Background: Switch-like and oscillatory dynamical systems are widely observed in biology. We investigate the simplest biological switch that is composed of a single molecule that can be autocatalytically converted between two opposing activity forms. We test how this simple network can keep its switching behaviour under perturbations in the system. Results: We show that this molecule can work as a robust bistable system, even for alterations in the reactions that drive the switching between various conformations. We propose that this single molecule system could work as a primitive biological sensor and show by steady state analysis of a mathematical model of the system that it could switch between possible states for changes in environmental signals. Particularly, we show that a single molecule phosphorylation-dephosphorylation switch could work as a nucleotide or energy sensor. We also notice that a given set of reductions in the reaction network can lead to the emergence of oscillatory behaviour. Conclusions: We propose that evolution could have converted this switch into a single molecule oscillator, which could have been used as a primitive timekeeper. We discuss how the structure of the simplest known circadian clock regulatory system, found in cyanobacteria, resembles the proposed single molecule oscillator. Besides, we speculate if such minimal systems could have existed in an RNA world.

KW - Approximate majority

KW - Bistability

KW - Circadian rhythm

KW - Computational biology

KW - Evolution

KW - Mathematical modelling

KW - Multistability

KW - Networks

KW - Oscillation

KW - RNA world

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U2 - 10.1186/s12918-018-0596-4

DO - 10.1186/s12918-018-0596-4

M3 - Article

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AN - SCOPUS:85048713628

VL - 12

JO - Bmc Systems Biology

JF - Bmc Systems Biology

SN - 1752-0509

IS - 1

M1 - 70

ER -

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