SiPM based preclinical PET/MR insert for a human 3T MR: first imaging experiments

Volkmar Schulz; Bjoern Weissler; Pierre Gebhardt; Torsten Solf; Christoph W. Lerche; Peter Fischer; Michael Ritzert; Viacheslav Mlotok; Claudio Piemonte; Benjamin Goldschmidt; Stefaan Vandenberghe; André Salomon; Tobias Schaeffter; Paul Marsden

SiPM based preclinical PET/MR insert for a human 3T MR: first imaging experiments

Volkmar Schulz, Bjoern Weissler, Pierre Gebhardt, Torsten Solf, Christoph W. Lerche, Peter Fischer, Michael Ritzert, Viacheslav Mlotok, Claudio Piemonte, Benjamin Goldschmidt, Stefaan Vandenberghe, André Salomon, Tobias Schaeffter, Paul Marsden

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

39 Citations (Scopus)

Abstract

Simultaneous PET/MRI is a hybrid imaging modality which promises to play an important role in the field of molecular imaging, as it combines the outstanding soft-tissue contrast of MRI with the metabolic and functional information of PET and MRI. In addition, the possibility for true simultaneous acquisition allows for improved 4D registration which in due course may lead to enhanced image quality and image quantification. The main technical challenges of simultaneous PET/MR are the MR-based attenuation correction and the development of an MR-compatible PET detector technology. Avalanche photo diode based detectors have been already successfully integrated into preclinical as well as human systems [1,2]. Low but noticeable interferences between PET and MRI have been reported so far. Unfortunately, these implementations do not offer the measurement of time of flight (TOF) information in the sub-ns range, which is one of the drivers for high quality clinical PET and has been state-of-the-art in clinical PET/CT for the last 5 years.

Original language	English
Title of host publication	Nuclear Science Symposium Conference Record (NSS/MIC)
Pages	4467-4469
Number of pages	3
Edition	2011
Publication status	Published - Nov 2011

Keywords

PET/MR
digital PET
preclinical

Cite this

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title = "SiPM based preclinical PET/MR insert for a human 3T MR: first imaging experiments",

abstract = "Simultaneous PET/MRI is a hybrid imaging modality which promises to play an important role in the field of molecular imaging, as it combines the outstanding soft-tissue contrast of MRI with the metabolic and functional information of PET and MRI. In addition, the possibility for true simultaneous acquisition allows for improved 4D registration which in due course may lead to enhanced image quality and image quantification. The main technical challenges of simultaneous PET/MR are the MR-based attenuation correction and the development of an MR-compatible PET detector technology. Avalanche photo diode based detectors have been already successfully integrated into preclinical as well as human systems [1,2]. Low but noticeable interferences between PET and MRI have been reported so far. Unfortunately, these implementations do not offer the measurement of time of flight (TOF) information in the sub-ns range, which is one of the drivers for high quality clinical PET and has been state-of-the-art in clinical PET/CT for the last 5 years.",

keywords = "PET/MR, digital PET, preclinical",

author = "Volkmar Schulz and Bjoern Weissler and Pierre Gebhardt and Torsten Solf and Lerche, {Christoph W.} and Peter Fischer and Michael Ritzert and Viacheslav Mlotok and Claudio Piemonte and Benjamin Goldschmidt and Stefaan Vandenberghe and Andr{\'e} Salomon and Tobias Schaeffter and Paul Marsden",

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AU - Schulz, Volkmar

AU - Weissler, Bjoern

AU - Gebhardt, Pierre

AU - Solf, Torsten

AU - Lerche, Christoph W.

AU - Fischer, Peter

AU - Ritzert, Michael

AU - Mlotok, Viacheslav

AU - Piemonte, Claudio

AU - Goldschmidt, Benjamin

AU - Vandenberghe, Stefaan

AU - Salomon, André

AU - Schaeffter, Tobias

AU - Marsden, Paul

PY - 2011/11

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N2 - Simultaneous PET/MRI is a hybrid imaging modality which promises to play an important role in the field of molecular imaging, as it combines the outstanding soft-tissue contrast of MRI with the metabolic and functional information of PET and MRI. In addition, the possibility for true simultaneous acquisition allows for improved 4D registration which in due course may lead to enhanced image quality and image quantification. The main technical challenges of simultaneous PET/MR are the MR-based attenuation correction and the development of an MR-compatible PET detector technology. Avalanche photo diode based detectors have been already successfully integrated into preclinical as well as human systems [1,2]. Low but noticeable interferences between PET and MRI have been reported so far. Unfortunately, these implementations do not offer the measurement of time of flight (TOF) information in the sub-ns range, which is one of the drivers for high quality clinical PET and has been state-of-the-art in clinical PET/CT for the last 5 years.

AB - Simultaneous PET/MRI is a hybrid imaging modality which promises to play an important role in the field of molecular imaging, as it combines the outstanding soft-tissue contrast of MRI with the metabolic and functional information of PET and MRI. In addition, the possibility for true simultaneous acquisition allows for improved 4D registration which in due course may lead to enhanced image quality and image quantification. The main technical challenges of simultaneous PET/MR are the MR-based attenuation correction and the development of an MR-compatible PET detector technology. Avalanche photo diode based detectors have been already successfully integrated into preclinical as well as human systems [1,2]. Low but noticeable interferences between PET and MRI have been reported so far. Unfortunately, these implementations do not offer the measurement of time of flight (TOF) information in the sub-ns range, which is one of the drivers for high quality clinical PET and has been state-of-the-art in clinical PET/CT for the last 5 years.

KW - PET/MR

KW - digital PET

KW - preclinical

M3 - Conference paper

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EP - 4469

BT - Nuclear Science Symposium Conference Record (NSS/MIC)

ER -

SiPM based preclinical PET/MR insert for a human 3T MR: first imaging experiments

Abstract

Keywords

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