Site specific measurements of bone formation using [¹⁸F] sodium fluoride PET/CT

TY - JOUR

T1 - Site specific measurements of bone formation using [18F] sodium fluoride PET/CT

AU - Blake, Glen M.

AU - Puri, Tanuj

AU - Siddique, Musib

AU - Frost, Michelle L.

AU - Moore, Amelia E.B.

AU - Fogelman, Ignac

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Dynamic positron emission tomography (PET) imaging with fluorine-18 labelled sodium fluoride ([18F]NaF) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. Today, hybrid PET and computed tomography (CT) dual-modality systems (PET/CT) are widely available, and [18F]NaF PET/CT offers a convenient noninvasive method of studying bone formation at the important osteoporotic fracture sites at the hip and spine, as well as sites of pure cortical or trabecular bone. The technique complements conventional measurements of bone turnover using biochemical markers or bone biopsy as a tool to investigate new therapies for osteoporosis, and has a potential role as an early biomarker of treatment effcacy in clinical trials. This article reviews methods of acquiring and analyzing dynamic [18F]NaF PET/CT scan data, and outlines a simplifed approach combining venous blood sampling with a series of short (3- to 5-minute) static PET/CT scans acquired at different bed positions to estimate [18F]NaF plasma clearance at multiple sites in the skeleton with just a single injection of tracer.

AB - Dynamic positron emission tomography (PET) imaging with fluorine-18 labelled sodium fluoride ([18F]NaF) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. Today, hybrid PET and computed tomography (CT) dual-modality systems (PET/CT) are widely available, and [18F]NaF PET/CT offers a convenient noninvasive method of studying bone formation at the important osteoporotic fracture sites at the hip and spine, as well as sites of pure cortical or trabecular bone. The technique complements conventional measurements of bone turnover using biochemical markers or bone biopsy as a tool to investigate new therapies for osteoporosis, and has a potential role as an early biomarker of treatment effcacy in clinical trials. This article reviews methods of acquiring and analyzing dynamic [18F]NaF PET/CT scan data, and outlines a simplifed approach combining venous blood sampling with a series of short (3- to 5-minute) static PET/CT scans acquired at different bed positions to estimate [18F]NaF plasma clearance at multiple sites in the skeleton with just a single injection of tracer.

KW - Bone blood flow

KW - Bone formation

KW - Bone plasma clearance

KW - Metabolic bone disease

KW - Osteoporosis

KW - Osteoporosis therapy

KW - Positron emission tomography (PET)

KW - Quantitative imaging

KW - Standardised uptake value

KW - [F] sodium fluoride ([F]NaF)

UR - http://www.scopus.com/inward/record.url?scp=85042753835&partnerID=8YFLogxK

U2 - 10.21037/qims.2018.01.02

DO - 10.21037/qims.2018.01.02

M3 - Review article

AN - SCOPUS:85042753835

SN - 2223-4292

VL - 8

SP - 47

EP - 59

JO - Quantitative Imaging in Medicine and Surgery

JF - Quantitative Imaging in Medicine and Surgery

IS - 1

ER -