Skeletal muscle dysfunction in critical care: Wasting, weakness, and rehabilitation strategies

TY - JOUR

T1 - Skeletal muscle dysfunction in critical care

T2 - Conference on Thinking Outside the Box

AU - Puthucheary, Zudin

AU - Harridge, Stephen

AU - Hart, Nicholas

PY - 2010/10

Y1 - 2010/10

N2 - Understanding the trajectory of skeletal muscle loss, evaluating its relationship to the subsequent functional impairment, and understanding the underlying mechanisms of skeletal muscle wasting will provide goals for novel treatment strategies in the intensive care setting. A focused approach on the effect of critical illness on muscle morphology, muscle protein turnover, and the associated muscle-signaling pathways during the early and recovery stages of critical illness is required. This could potentially lead to targeted pharmacologic and nonpharmacologic strategies to treat, or even prevent, peripheral muscle wasting and weakness.

AB - Understanding the trajectory of skeletal muscle loss, evaluating its relationship to the subsequent functional impairment, and understanding the underlying mechanisms of skeletal muscle wasting will provide goals for novel treatment strategies in the intensive care setting. A focused approach on the effect of critical illness on muscle morphology, muscle protein turnover, and the associated muscle-signaling pathways during the early and recovery stages of critical illness is required. This could potentially lead to targeted pharmacologic and nonpharmacologic strategies to treat, or even prevent, peripheral muscle wasting and weakness.

UR - http://www.scopus.com/inward/record.url?scp=78650321319&partnerID=8YFLogxK

U2 - 10.1097/CCM.0b013e3181f2458d

DO - 10.1097/CCM.0b013e3181f2458d

M3 - Conference paper

SN - 1530-0293

VL - 38

SP - S676 - S682

JO - Critical Care Medicine

JF - Critical Care Medicine

IS - 10 SUPPL.

Y2 - 1 March 2010

ER -