Sleep and cognitive aging in the eighth decade of life

Simon Cox; Stuart James Ritchie; Mike Allerhand; Saskia Petronella Hagenaars; Ratko Radakovic; David Breen; Gail Davies; Renata Riha; Sarah Harris; John M. Starr; Ian Deary

doi:10.1093/sleep/zsz019

Sleep and cognitive aging in the eighth decade of life

Simon Cox, Stuart James Ritchie, Mike Allerhand, Saskia Petronella Hagenaars, Ratko Radakovic, David Breen, Gail Davies, Renata Riha, Sarah Harris, John M. Starr, Ian Deary

University of Edinburgh

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

We examined associations between self-reported sleep measures and cognitive level and change (age 70-76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype and sleep duration related to self-reported sleep, and to cognitive level and change. Shorter sleep latency was associated with significantly higher levels of visuospatial ability, processing speed, and verbal memory (β ≥ |0.184|, SE ≤ 0.075, p ≤ 0.003). Longer daytime sleep duration was significantly associated slower processing speed (β = â '0.085, SE = 0.027, p = 0.001), and with steeper 6-year decline in visuospatial reasoning (β = â '0.009, SE = 0.003, p = 0.008), and processing speed (β = â '0.009, SE = 0.002, p < 0.001). Only longitudinal associations between longer daytime sleeping and steeper cognitive declines survived correction for important health covariates and false discovery rate (FDR). PGS of chronotype and sleep duration were nominally associated with specific self-reported sleep characteristics for most SNP thresholds (standardized β range = |0.123 to 0.082|, p range = 0.003 to 0.046), but neither PGS predicted cognitive level or change following FDR. Daytime sleep duration is a potentially important correlate of cognitive decline in visuospatial reasoning and processing speed in older age, whereas cross-sectional associations are partially confounded by important health factors. A genetic propensity toward morningness and sleep duration were weakly, but consistently, related to self-reported sleep characteristics, and did not relate to cognitive level or change.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Sleep
Volume	42
Issue number	4
DOIs	https://doi.org/10.1093/sleep/zsz019
Publication status	Published - 12 Feb 2019

Keywords

cognitive aging
daytime sleep
polygenic scores

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10.1093/sleep/zsz019

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title = "Sleep and cognitive aging in the eighth decade of life",

abstract = "We examined associations between self-reported sleep measures and cognitive level and change (age 70-76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype and sleep duration related to self-reported sleep, and to cognitive level and change. Shorter sleep latency was associated with significantly higher levels of visuospatial ability, processing speed, and verbal memory (β ≥ |0.184|, SE ≤ 0.075, p ≤ 0.003). Longer daytime sleep duration was significantly associated slower processing speed (β = {\^a} '0.085, SE = 0.027, p = 0.001), and with steeper 6-year decline in visuospatial reasoning (β = {\^a} '0.009, SE = 0.003, p = 0.008), and processing speed (β = {\^a} '0.009, SE = 0.002, p < 0.001). Only longitudinal associations between longer daytime sleeping and steeper cognitive declines survived correction for important health covariates and false discovery rate (FDR). PGS of chronotype and sleep duration were nominally associated with specific self-reported sleep characteristics for most SNP thresholds (standardized β range = |0.123 to 0.082|, p range = 0.003 to 0.046), but neither PGS predicted cognitive level or change following FDR. Daytime sleep duration is a potentially important correlate of cognitive decline in visuospatial reasoning and processing speed in older age, whereas cross-sectional associations are partially confounded by important health factors. A genetic propensity toward morningness and sleep duration were weakly, but consistently, related to self-reported sleep characteristics, and did not relate to cognitive level or change.",

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T1 - Sleep and cognitive aging in the eighth decade of life

AU - Cox, Simon

AU - Ritchie, Stuart James

AU - Allerhand, Mike

AU - Hagenaars, Saskia Petronella

AU - Radakovic, Ratko

AU - Breen, David

AU - Davies, Gail

AU - Riha, Renata

AU - Harris, Sarah

AU - Starr, John M.

AU - Deary, Ian

PY - 2019/2/12

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N2 - We examined associations between self-reported sleep measures and cognitive level and change (age 70-76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype and sleep duration related to self-reported sleep, and to cognitive level and change. Shorter sleep latency was associated with significantly higher levels of visuospatial ability, processing speed, and verbal memory (β ≥ |0.184|, SE ≤ 0.075, p ≤ 0.003). Longer daytime sleep duration was significantly associated slower processing speed (β = â '0.085, SE = 0.027, p = 0.001), and with steeper 6-year decline in visuospatial reasoning (β = â '0.009, SE = 0.003, p = 0.008), and processing speed (β = â '0.009, SE = 0.002, p < 0.001). Only longitudinal associations between longer daytime sleeping and steeper cognitive declines survived correction for important health covariates and false discovery rate (FDR). PGS of chronotype and sleep duration were nominally associated with specific self-reported sleep characteristics for most SNP thresholds (standardized β range = |0.123 to 0.082|, p range = 0.003 to 0.046), but neither PGS predicted cognitive level or change following FDR. Daytime sleep duration is a potentially important correlate of cognitive decline in visuospatial reasoning and processing speed in older age, whereas cross-sectional associations are partially confounded by important health factors. A genetic propensity toward morningness and sleep duration were weakly, but consistently, related to self-reported sleep characteristics, and did not relate to cognitive level or change.

AB - We examined associations between self-reported sleep measures and cognitive level and change (age 70-76 years) in a longitudinal, same-year-of-birth cohort study (baseline N = 1091; longitudinal N = 664). We also leveraged GWAS summary data to ascertain whether polygenic scores (PGS) of chronotype and sleep duration related to self-reported sleep, and to cognitive level and change. Shorter sleep latency was associated with significantly higher levels of visuospatial ability, processing speed, and verbal memory (β ≥ |0.184|, SE ≤ 0.075, p ≤ 0.003). Longer daytime sleep duration was significantly associated slower processing speed (β = â '0.085, SE = 0.027, p = 0.001), and with steeper 6-year decline in visuospatial reasoning (β = â '0.009, SE = 0.003, p = 0.008), and processing speed (β = â '0.009, SE = 0.002, p < 0.001). Only longitudinal associations between longer daytime sleeping and steeper cognitive declines survived correction for important health covariates and false discovery rate (FDR). PGS of chronotype and sleep duration were nominally associated with specific self-reported sleep characteristics for most SNP thresholds (standardized β range = |0.123 to 0.082|, p range = 0.003 to 0.046), but neither PGS predicted cognitive level or change following FDR. Daytime sleep duration is a potentially important correlate of cognitive decline in visuospatial reasoning and processing speed in older age, whereas cross-sectional associations are partially confounded by important health factors. A genetic propensity toward morningness and sleep duration were weakly, but consistently, related to self-reported sleep characteristics, and did not relate to cognitive level or change.

KW - cognitive aging

KW - daytime sleep

KW - polygenic scores

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U2 - 10.1093/sleep/zsz019

DO - 10.1093/sleep/zsz019

M3 - Article

SN - 0161-8105

VL - 42

SP - 1

EP - 12

JO - Sleep

JF - Sleep

IS - 4

ER -

Sleep and cognitive aging in the eighth decade of life

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Keywords

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