Slice-illuminated optical projection tomography

Samuel P.X. Davis*, Laura Wisniewski, Sunil Kumar, Teresa Correia, Simon R. Arridge, Paul Frankel, James McGinty, Paul M.W. French

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

To improve the imaging performance of optical projection tomography (OPT) in live samples, we have explored a parallelized implementation of semi-confocal line illumination and detection to discriminate against scattered photons. Slice-illuminated OPT (sl-OPT) improves reconstruction quality in scattering samples by reducing interpixel crosstalk at the cost of increased acquisition time. For in vivo imaging, this can be ameliorated through the use of compressed sensing on angularly undersampled OPT data sets. Here, we demonstrate sl-OPT applied to 3D imaging of bead phantoms and live adult zebrafish.

Original languageEnglish
Pages (from-to)5555-5558
Number of pages4
JournalOptics Letters
Volume43
Issue number22
DOIs
Publication statusPublished - 15 Nov 2018

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