Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Karen Horsburgh; Joanna M. Wardlaw; Tom van Agtmael; Stuart M. Allan; Mike L.J. Ashford; Philip M. Bath; Rosalind Brown; Jason Berwick; M. Zameel Cader; Roxana O. Carare; John B. Davis; Jessica Duncombe; Tracy D. Farr; Jill H. Fowler; Jozien Goense; Alessandra Granata; Catherine N. Hall; Atticus H. Hainsworth; Adam Harvey; Cheryl A. Hawkes; Anne Joutel; Rajesh N. Kalaria; Patrick G. Kehoe; Catherine B. Lawrence; Andy Lockhart; Seth Love; Malcolm R. Macleod; I. Mhairi Macrae; Hugh S. Markus; Chris McCabe; Barry W. McColl; Paul J. Meakin; Alyson Miller; Maiken Nedergaard; Michael O'Sullivan; Terry J. Quinn; Rikesh Rajani; Lisa M. Saksida; Colin Smith; Kenneth J. Smith; Rhian M. Touyz; Rebecca C. Trueman; Tao Wang; Anna Williams; Steven C.R. Williams; Lorraine M. Work

doi:10.1042/CS20171620

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Karen Horsburgh^*, Joanna M. Wardlaw, Tom van Agtmael, Stuart M. Allan, Mike L.J. Ashford, Philip M. Bath, Rosalind Brown, Jason Berwick, M. Zameel Cader, Roxana O. Carare, John B. Davis, Jessica Duncombe, Tracy D. Farr, Jill H. Fowler, Jozien Goense, Alessandra Granata, Catherine N. Hall, Atticus H. Hainsworth, Adam Harvey, Cheryl A. HawkesAnne Joutel, Rajesh N. Kalaria, Patrick G. Kehoe, Catherine B. Lawrence, Andy Lockhart, Seth Love, Malcolm R. Macleod, I. Mhairi Macrae, Hugh S. Markus, Chris McCabe, Barry W. McColl, Paul J. Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J. Quinn, Rikesh Rajani, Lisa M. Saksida, Colin Smith, Kenneth J. Smith, Rhian M. Touyz, Rebecca C. Trueman, Tao Wang, Anna Williams, Steven C.R. Williams, Lorraine M. Work

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

158 Downloads (Pure)

Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Original language	English
Pages (from-to)	851-868
Number of pages	18
Journal	Clinical Science
Volume	132
Issue number	8
Early online date	30 Apr 2018
DOIs	https://doi.org/10.1042/CS20171620
Publication status	Published - Apr 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1042/CS20171620

Small vessels, dementia and_HORSBURGH_Accepted21February2018_GREEN AAMAccepted author manuscript, 677 KB

Cite this

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., ... Work, L. M. (2018). Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132(8), 851-868. https://doi.org/10.1042/CS20171620

@article{35579bf7a8dc4e0a855a490b6290da45,

title = "Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology",

abstract = "Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.",

author = "Karen Horsburgh and Wardlaw, {Joanna M.} and {van Agtmael}, Tom and Allan, {Stuart M.} and Ashford, {Mike L.J.} and Bath, {Philip M.} and Rosalind Brown and Jason Berwick and Cader, {M. Zameel} and Carare, {Roxana O.} and Davis, {John B.} and Jessica Duncombe and Farr, {Tracy D.} and Fowler, {Jill H.} and Jozien Goense and Alessandra Granata and Hall, {Catherine N.} and Hainsworth, {Atticus H.} and Adam Harvey and Hawkes, {Cheryl A.} and Anne Joutel and Kalaria, {Rajesh N.} and Kehoe, {Patrick G.} and Lawrence, {Catherine B.} and Andy Lockhart and Seth Love and Macleod, {Malcolm R.} and Macrae, {I. Mhairi} and Markus, {Hugh S.} and Chris McCabe and McColl, {Barry W.} and Meakin, {Paul J.} and Alyson Miller and Maiken Nedergaard and Michael O'Sullivan and Quinn, {Terry J.} and Rikesh Rajani and Saksida, {Lisa M.} and Colin Smith and Smith, {Kenneth J.} and Touyz, {Rhian M.} and Trueman, {Rebecca C.} and Tao Wang and Anna Williams and Williams, {Steven C.R.} and Work, {Lorraine M.}",

year = "2018",

month = apr,

doi = "10.1042/CS20171620",

language = "English",

volume = "132",

pages = "851--868",

journal = "Clinical Science",

issn = "0143-5221",

publisher = "Portland Press Ltd.",

number = "8",

}

Horsburgh, K, Wardlaw, JM, van Agtmael, T, Allan, SM, Ashford, MLJ, Bath, PM, Brown, R, Berwick, J, Cader, MZ, Carare, RO, Davis, JB, Duncombe, J, Farr, TD, Fowler, JH, Goense, J, Granata, A, Hall, CN, Hainsworth, AH, Harvey, A, Hawkes, CA, Joutel, A, Kalaria, RN, Kehoe, PG, Lawrence, CB, Lockhart, A, Love, S, Macleod, MR, Macrae, IM, Markus, HS, McCabe, C, McColl, BW, Meakin, PJ, Miller, A, Nedergaard, M, O'Sullivan, M, Quinn, TJ, Rajani, R, Saksida, LM, Smith, C, Smith, KJ, Touyz, RM, Trueman, RC, Wang, T, Williams, A, Williams, SCR & Work, LM 2018, 'Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology', Clinical Science, vol. 132, no. 8, pp. 851-868. https://doi.org/10.1042/CS20171620

TY - JOUR

T1 - Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

AU - Horsburgh, Karen

AU - Wardlaw, Joanna M.

AU - van Agtmael, Tom

AU - Allan, Stuart M.

AU - Ashford, Mike L.J.

AU - Bath, Philip M.

AU - Brown, Rosalind

AU - Berwick, Jason

AU - Cader, M. Zameel

AU - Carare, Roxana O.

AU - Davis, John B.

AU - Duncombe, Jessica

AU - Farr, Tracy D.

AU - Fowler, Jill H.

AU - Goense, Jozien

AU - Granata, Alessandra

AU - Hall, Catherine N.

AU - Hainsworth, Atticus H.

AU - Harvey, Adam

AU - Hawkes, Cheryl A.

AU - Joutel, Anne

AU - Kalaria, Rajesh N.

AU - Kehoe, Patrick G.

AU - Lawrence, Catherine B.

AU - Lockhart, Andy

AU - Love, Seth

AU - Macleod, Malcolm R.

AU - Macrae, I. Mhairi

AU - Markus, Hugh S.

AU - McCabe, Chris

AU - McColl, Barry W.

AU - Meakin, Paul J.

AU - Miller, Alyson

AU - Nedergaard, Maiken

AU - O'Sullivan, Michael

AU - Quinn, Terry J.

AU - Rajani, Rikesh

AU - Saksida, Lisa M.

AU - Smith, Colin

AU - Smith, Kenneth J.

AU - Touyz, Rhian M.

AU - Trueman, Rebecca C.

AU - Wang, Tao

AU - Williams, Anna

AU - Williams, Steven C.R.

AU - Work, Lorraine M.

PY - 2018/4

Y1 - 2018/4

N2 - Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

AB - Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

UR - http://www.scopus.com/inward/record.url?scp=85046543986&partnerID=8YFLogxK

U2 - 10.1042/CS20171620

DO - 10.1042/CS20171620

M3 - Article

AN - SCOPUS:85046543986

SN - 0143-5221

VL - 132

SP - 851

EP - 868

JO - Clinical Science

JF - Clinical Science

IS - 8

ER -

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this