Smooth muscle in tissue remodeling and hyper-reactivity: Airways and arteries

Kristina Rydell-Törmänen, Paul André Risse, Varsha Kanabar, Rushita Bagchi, Michael P. Czubryt, Jill R. Johnson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalPulmonary pharmacology & therapeutics
Volume26
Issue number1
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Airway smooth muscle
  • Animal models
  • Asthma
  • Chronic obstructive pulmonary disease
  • Pulmonary hypertension
  • Vascular smooth muscle

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