SOLID-PHASE SYNTHESIS OF 5-HYDROXYMETHYLURACIL CONTAINING DNA

M R  CONTE; A  GALEONE; D  AVIZONIS; V L  HSU; L  MAYOL; D R  KEARNS

doi:10.1016/S0960-894X(00)80660-5

SOLID-PHASE SYNTHESIS OF 5-HYDROXYMETHYLURACIL CONTAINING DNA

M R CONTE, A GALEONE, D AVIZONIS, V L HSU, L MAYOL, D R KEARNS

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Abstract

The synthesis of 3'-O-(diisopropylamino-2-cyanoethoxyphosphinyl)-5-O-(4,4'-dimethoxytrityl)-5-(tert-butyldimethylsiloxymethyl)-2'-deoxyuridine (5) and its utilization for the preparation of 5-hydroxymethyluracil (hmU) containing oligodeoxyribonucleotides by means of automated synthesis are described.

Original language	English
Pages (from-to)	79-82
Number of pages	4
Journal	BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/S0960-894X(00)80660-5
Publication status	Published - 1992

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10.1016/S0960-894X(00)80660-5

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title = "SOLID-PHASE SYNTHESIS OF 5-HYDROXYMETHYLURACIL CONTAINING DNA",

abstract = "The synthesis of 3'-O-(diisopropylamino-2-cyanoethoxyphosphinyl)-5-O-(4,4'-dimethoxytrityl)-5-(tert-butyldimethylsiloxymethyl)-2'-deoxyuridine (5) and its utilization for the preparation of 5-hydroxymethyluracil (hmU) containing oligodeoxyribonucleotides by means of automated synthesis are described.",

author = "CONTE, {M R} and A GALEONE and D AVIZONIS and HSU, {V L} and L MAYOL and KEARNS, {D R}",

year = "1992",

doi = "10.1016/S0960-894X(00)80660-5",

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pages = "79--82",

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T1 - SOLID-PHASE SYNTHESIS OF 5-HYDROXYMETHYLURACIL CONTAINING DNA

AU - CONTE, M R

AU - GALEONE, A

AU - AVIZONIS, D

AU - HSU, V L

AU - MAYOL, L

AU - KEARNS, D R

PY - 1992

Y1 - 1992

N2 - The synthesis of 3'-O-(diisopropylamino-2-cyanoethoxyphosphinyl)-5-O-(4,4'-dimethoxytrityl)-5-(tert-butyldimethylsiloxymethyl)-2'-deoxyuridine (5) and its utilization for the preparation of 5-hydroxymethyluracil (hmU) containing oligodeoxyribonucleotides by means of automated synthesis are described.

AB - The synthesis of 3'-O-(diisopropylamino-2-cyanoethoxyphosphinyl)-5-O-(4,4'-dimethoxytrityl)-5-(tert-butyldimethylsiloxymethyl)-2'-deoxyuridine (5) and its utilization for the preparation of 5-hydroxymethyluracil (hmU) containing oligodeoxyribonucleotides by means of automated synthesis are described.

U2 - 10.1016/S0960-894X(00)80660-5

DO - 10.1016/S0960-894X(00)80660-5

M3 - Article

SN - 0960-894X

VL - 2

SP - 79

EP - 82

JO - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

JF - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

IS - 1

ER -

SOLID-PHASE SYNTHESIS OF 5-HYDROXYMETHYLURACIL CONTAINING DNA

Abstract

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