Sox14 is required for a specific subset of cerebello–olivary projections

Hong-Ting Prekop, Anna Kroiss, Victoria Rook, Laskaro Zagoraiou, Thomas Jessell, Catherine Fernandes, Alessio Delogu*, Richard J. T. Wingate

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
136 Downloads (Pure)

Abstract

We identify Sox14 as an exclusive marker of inhibitory projection neurons in the lateral and interposed, but not the medial, cerebellar nuclei. Sox14+ neurons make up ~80% of Gad1+ neurons in these nuclei and are indistinguishable by soma size from other inhibitory neurons. All Sox14+ neurons of the lateral and interposed cerebellar nuclei are generated at approximately E10/10.5 and extend long-range, predominantly contralateral projections to the inferior olive. A small Sox14+ population in the adjacent vestibular nucleus “Y” sends an ipsilateral projection to the oculomotor nucleus. Cerebellar Sox14+ and glutamatergic projection neurons assemble in non-overlapping populations at the nuclear transition zone, and their integration into a coherent nucleus depends on Sox14 function. Targeted ablation of Sox14+ cells by conditional viral expression of diphtheria toxin leads to significantly impaired motor learning. Contrary to expectations, associative learning is unaffected by unilateral Sox14+ neuron elimination in the interposed and lateral nuclei.

Original languageEnglish
Pages (from-to)9539-9550
Number of pages12
JournalJournal of Neuroscience
Volume38
Issue number44
Early online date31 Oct 2018
DOIs
Publication statusPublished - 2018

Keywords

  • Axon
  • Cerebellum
  • GABA
  • Genetic model
  • Inferior olive
  • Motor learning

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