Research output: Contribution to journal › Article › peer-review
Hong-Ting Prekop, Anna Kroiss, Victoria Rook, Laskaro Zagoraiou, Thomas Jessell, Catherine Fernandes, Alessio Delogu, Richard J. T. Wingate
Original language | English |
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Pages (from-to) | 9539-9550 |
Number of pages | 12 |
Journal | Journal of Neuroscience |
Volume | 38 |
Issue number | 44 |
Early online date | 31 Oct 2018 |
DOIs | |
Accepted/In press | 4 Sep 2018 |
E-pub ahead of print | 31 Oct 2018 |
Published | 2018 |
Additional links |
Sox14 is required for_PREKOP_Accepted4September2018_GREEN AAM
Sox14_is_required_for_PREKOP_Accepted4September2018_GREEN_AAM.pdf, 4.42 MB, application/pdf
Uploaded date:17 Dec 2018
Version:Accepted author manuscript
We identify Sox14 as an exclusive marker of inhibitory projection neurons in the lateral and interposed, but not the medial, cerebellar nuclei. Sox14+ neurons make up ~80% of Gad1+ neurons in these nuclei and are indistinguishable by soma size from other inhibitory neurons. All Sox14+ neurons of the lateral and interposed cerebellar nuclei are generated at approximately E10/10.5 and extend long-range, predominantly contralateral projections to the inferior olive. A small Sox14+ population in the adjacent vestibular nucleus “Y” sends an ipsilateral projection to the oculomotor nucleus. Cerebellar Sox14+ and glutamatergic projection neurons assemble in non-overlapping populations at the nuclear transition zone, and their integration into a coherent nucleus depends on Sox14 function. Targeted ablation of Sox14+ cells by conditional viral expression of diphtheria toxin leads to significantly impaired motor learning. Contrary to expectations, associative learning is unaffected by unilateral Sox14+ neuron elimination in the interposed and lateral nuclei.
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