TY - JOUR
T1 - Sozinibercept Combination Therapy for Neovascular Age-related Macular Degeneration
T2 - Phase 2b Study Subgroup Analysis by Lesion Type
AU - Wykoff, Charles C
AU - Jackson, Timothy L
AU - Price, Clare F
AU - Baldwin, Megan E
AU - Leitch, Ian M
AU - Slakter, Jason
N1 - Publisher Copyright:
© 2025 Wykoff, Jackson, Price, et al.;
PY - 2025/2/1
Y1 - 2025/2/1
N2 - BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the angiographic predictors of response to the anti-vascular endothelial growth factor-C/-D agent, sozinibercept. PATIENTS AND METHODS: Prespecified and post hoc subgroup analyses of a phase 2b, randomized, double-masked, sham-controlled trial of 240 participants with treatment-naïve neovascular age-related macular degeneration, comparing monthly intravitreal sozinibercept 0.5 mg or 2 mg, plus ranibizumab 0.5 mg, versus monthly ranibizumab monotherapy. RESULTS: Visual acuity benefits at week 24 were greatest in participants with occult lesions receiving 2 mg sozinibercept combination therapy (+15.65 [n = 53] letters versus +9.62 [n = 51] with ranibizumab monotherapy; least squares mean difference +6.03; P = 0.0009). A composite analysis of occult and minimally classic lesions excluding retinal angiomatous proliferation (n = 175/240) also favored sozinibercept over control (+16.08 versus +10.34 letters; +5.74; P = 0.0002). Structural outcomes mirrored sozinibercept visual acuity benefits, with less leakage and smaller lesions on multimodal imaging. CONCLUSION: Angiographic lesion characteristics were found to predict the response to sozinibercept combination therapy.
AB - BACKGROUND AND OBJECTIVE: The purpose of this study was to evaluate the angiographic predictors of response to the anti-vascular endothelial growth factor-C/-D agent, sozinibercept. PATIENTS AND METHODS: Prespecified and post hoc subgroup analyses of a phase 2b, randomized, double-masked, sham-controlled trial of 240 participants with treatment-naïve neovascular age-related macular degeneration, comparing monthly intravitreal sozinibercept 0.5 mg or 2 mg, plus ranibizumab 0.5 mg, versus monthly ranibizumab monotherapy. RESULTS: Visual acuity benefits at week 24 were greatest in participants with occult lesions receiving 2 mg sozinibercept combination therapy (+15.65 [n = 53] letters versus +9.62 [n = 51] with ranibizumab monotherapy; least squares mean difference +6.03; P = 0.0009). A composite analysis of occult and minimally classic lesions excluding retinal angiomatous proliferation (n = 175/240) also favored sozinibercept over control (+16.08 versus +10.34 letters; +5.74; P = 0.0002). Structural outcomes mirrored sozinibercept visual acuity benefits, with less leakage and smaller lesions on multimodal imaging. CONCLUSION: Angiographic lesion characteristics were found to predict the response to sozinibercept combination therapy.
UR - http://www.scopus.com/inward/record.url?scp=105005196756&partnerID=8YFLogxK
U2 - 10.3928/23258160-20250108-04
DO - 10.3928/23258160-20250108-04
M3 - Article
C2 - 39999360
SN - 2325-8160
VL - 56
SP - 287
EP - 296
JO - Ophthalmic surgery, lasers & imaging retina
JF - Ophthalmic surgery, lasers & imaging retina
IS - 5
ER -