Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

G Griesel; D Treichel; P Collombat; J Krull; A Zembrzycki; W M R van den Akker; P Gruss; A Simeone; A Mansouri

doi:10.1242/dev.02326

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

G Griesel, D Treichel, P Collombat, J Krull, A Zembrzycki, W M R van den Akker, P Gruss, A Simeone, A Mansouri

King's College London

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The specification of neuronal cell types in the developing neural tube is orchestrated by signaling centers. However, how patterned territories of the central nervous system (CNS) are organized into structures with appropriate size and shape is still unclear. We report that in the absence of the mouse transcription factor mBtd/Sp8, a posterior shift of the isthmic organizer (IsO) occurs, suggesting a crucial role for Sp8 in this process. In addition, large patches of cells ectopically expressing Fgf8, Otx2 and/or Wnt1 in the rostral hindbrain are detected in Sp8 mutant embryos. In this context, midbrain dopaminergic neurons are found posterior to the IsO. Furthermore, we provide evidence that cell proliferation in the mid- and hindbrain is tightly controlled by Sp8 activity. Our observations are consistent with a role for Sp8 in restricting Fgf8 expression at the IsO

Original language	English
Pages (from-to)	1779 - 1787
Number of pages	9
Journal	Development (Cambridge): for advances in developmental biology and stem cells
Volume	133
Issue number	9
DOIs	https://doi.org/10.1242/dev.02326
Publication status	Published - May 2006

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title = "Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border",

abstract = "The specification of neuronal cell types in the developing neural tube is orchestrated by signaling centers. However, how patterned territories of the central nervous system (CNS) are organized into structures with appropriate size and shape is still unclear. We report that in the absence of the mouse transcription factor mBtd/Sp8, a posterior shift of the isthmic organizer (IsO) occurs, suggesting a crucial role for Sp8 in this process. In addition, large patches of cells ectopically expressing Fgf8, Otx2 and/or Wnt1 in the rostral hindbrain are detected in Sp8 mutant embryos. In this context, midbrain dopaminergic neurons are found posterior to the IsO. Furthermore, we provide evidence that cell proliferation in the mid- and hindbrain is tightly controlled by Sp8 activity. Our observations are consistent with a role for Sp8 in restricting Fgf8 expression at the IsO",

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AU - Griesel, G

AU - Treichel, D

AU - Collombat, P

AU - Krull, J

AU - Zembrzycki, A

AU - van den Akker, W M R

AU - Gruss, P

AU - Simeone, A

AU - Mansouri, A

PY - 2006/5

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DO - 10.1242/dev.02326

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Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

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