Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Roxanne C Keynejad; Hana Marková; Kamila Šiffelová; Naveen Kumar; Kamil Vlček; Jan Laczó; Ellen M Migo; Jakub Hort; Michael D Kopelman

doi:10.1080/13825585.2017.1290212

Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Roxanne C Keynejad^*, Hana Marková, Kamila Šiffelová, Naveen Kumar, Kamil Vlček, Jan Laczó, Ellen M Migo, Jakub Hort, Michael D Kopelman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

AIMS: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).

METHODS: We recruited aMCI patients with (n = 21) and without (n = 21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n = 22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.

RESULTS: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.

CONCLUSIONS: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess "pure" aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	Aging, Neuropsychology and Cognition
Early online date	28 Feb 2017
DOIs	https://doi.org/10.1080/13825585.2017.1290212
Publication status	Published - 28 Feb 2017

Keywords

Mild cognitive impairment
neuropsychiatric comorbidity
spatial memory
spatial navigation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/13825585.2017.1290212

Spatial navigation deficits in_KEYNEJAD_Publishedonline28February2017_GREEN AAMAccepted author manuscript, 438 KB

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abstract = "AIMS: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).METHODS: We recruited aMCI patients with (n = 21) and without (n = 21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n = 22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.RESULTS: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.CONCLUSIONS: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess {"}pure{"} aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.",

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AU - Keynejad, Roxanne C

AU - Marková, Hana

AU - Šiffelová, Kamila

AU - Kumar, Naveen

AU - Vlček, Kamil

AU - Laczó, Jan

AU - Migo, Ellen M

AU - Hort, Jakub

AU - Kopelman, Michael D

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N2 - AIMS: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).METHODS: We recruited aMCI patients with (n = 21) and without (n = 21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n = 22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.RESULTS: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.CONCLUSIONS: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess "pure" aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.

AB - AIMS: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).METHODS: We recruited aMCI patients with (n = 21) and without (n = 21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n = 22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.RESULTS: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.CONCLUSIONS: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess "pure" aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.

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KW - neuropsychiatric comorbidity

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KW - spatial navigation

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JO - Aging, Neuropsychology and Cognition

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Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Abstract

Keywords

UN SDGs

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