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Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia

Research output: Contribution to journalArticle

A. D. Edwards, X. Yue, M. V. Squier, M. Thoresen, E. B. Cady, J. Penrice, C. E. Cooper, J. S. Wyatt, E. O. Reynolds, H. Mehmet

Original languageEnglish
Pages (from-to)1193-1199
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume217
Issue number3
DOIs
Publication statusPublished - 1995

Bibliographical note

M1 - 3 Edwards, A D Yue, X Squier, M V Thoresen, M Cady, E B Penrice, J Cooper, C E Wyatt, J S Reynolds, E O Mehmet, H United states Biochemical and biophysical research communications Biochem Biophys Res Commun. 1995 Dec 26;217(3):1193-9.

King's Authors

Abstract

In piglets studied on the first day of life transient hypoxia-ischaemia caused an increase in the fractions of necrotic and apoptotic cells in the cingulate sulcus compared to sham-operated controls. In animals subjected to the same hypoxic-ischaemic insult but cooled to 34.9 degrees C (mean tympanic membrane temperature) for 12 hours commencing after resuscitation the fraction of cells undergoing necrosis was unchanged and comparable to that in animals which were not cooled. However, the fraction of apoptotic cells was reduced and was similar to that in sham-operated controls. Thus hypothermia specifically inhibited apoptosis. This result has implications for understanding the mechanisms of delayed cerebral injury and for the use of hypothermia as a neural rescue strategy in the developing brain.

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