Spectroscopic imaging applied to drug release

TY - JOUR

T1 - Spectroscopic imaging applied to drug release

AU - Kazarian, SG

AU - Kong, KWT

AU - Bajomo, M

AU - Van der Weerd, J

AU - Chan, KLA

PY - 2005/6

Y1 - 2005/6

N2 - Fourier transform infrared (FTIR) imaging is a powerful tool to characterize the distribution of different chemicals in heterogeneous materials. Tremendous potential exists in applications of FTIR imaging to dynamic processes in aqueous solutions due to the ability of the focal plane array (FPA) infrared imaging detector to collect many spectra simultaneously and spatially resolved information of a large area at the polymer-water interface.We have applied FTIR imaging combined with a dissolution test via UV detection in a novel way to study the dissolution of tablets prepared by solid dispersion of drugs in polymer. The advantages of macro ATR imaging in the study of drugs are demonstrated. Concentration profiles of the drug dissolved in water were measured as a function of time, the effects of drug loading is studied and the mechanism of the dissolution of a polymer in water is elucidated. Images of the distribution of drug and polymer, and the evolution of these distributions as a function of time have been obtained. The effects of tablet preparation methods were also investigated using this imaging approach. This study unravels the mechanism of drug release from selected solid dispersions and answers the question pertaining to whether drug release proceeds via polymer degradation or drug diffusion.This FTIR imaging approach has also provided a valuable dataset for the modelling of polymer dissolution and drug release. This research demonstrates that FTIR imaging can be a powerful tool in the investigation of solid dispersions, polymer/drug interactions and their relevance to controlled drug release processes.

AB - Fourier transform infrared (FTIR) imaging is a powerful tool to characterize the distribution of different chemicals in heterogeneous materials. Tremendous potential exists in applications of FTIR imaging to dynamic processes in aqueous solutions due to the ability of the focal plane array (FPA) infrared imaging detector to collect many spectra simultaneously and spatially resolved information of a large area at the polymer-water interface.We have applied FTIR imaging combined with a dissolution test via UV detection in a novel way to study the dissolution of tablets prepared by solid dispersion of drugs in polymer. The advantages of macro ATR imaging in the study of drugs are demonstrated. Concentration profiles of the drug dissolved in water were measured as a function of time, the effects of drug loading is studied and the mechanism of the dissolution of a polymer in water is elucidated. Images of the distribution of drug and polymer, and the evolution of these distributions as a function of time have been obtained. The effects of tablet preparation methods were also investigated using this imaging approach. This study unravels the mechanism of drug release from selected solid dispersions and answers the question pertaining to whether drug release proceeds via polymer degradation or drug diffusion.This FTIR imaging approach has also provided a valuable dataset for the modelling of polymer dissolution and drug release. This research demonstrates that FTIR imaging can be a powerful tool in the investigation of solid dispersions, polymer/drug interactions and their relevance to controlled drug release processes.

KW - FTIR imaging

KW - ATR-IR

KW - USP

KW - dissolution

KW - pharmaceutical tablets

KW - DELIVERY SYSTEMS

KW - PHARMACEUTICAL FORMULATIONS

KW - SOLID DISPERSIONS

KW - DISSOLUTION

U2 - 10.1205/fbp.04399

DO - 10.1205/fbp.04399

M3 - Article

SN - 0960-3085

VL - 83

SP - 127

EP - 135

JO - FOOD AND BIOPRODUCTS PROCESSING

JF - FOOD AND BIOPRODUCTS PROCESSING

IS - 2

T2 - 7th World Congress of Chemical Engineering

Y2 - 10 July 2005 through 14 July 2005

ER -