Spotlight Issue: MicroRNAs in the MicrocirculationuFrom Cellular Mechanisms to Clinical Markers

Richard C. M. Siow, Geraldine F. Clough

Research output: Contribution to journalEditorialpeer-review

3 Citations (Scopus)

Abstract

This spotlight issue of Microcirculation contains four state-of-the-art review articles on the role of microRNAs (miRNAs), a class of endogenous, highly conserved, small, non-coding RNAs that regulate gene expression at the post transcriptional level, and can act as key regulators of cellular mechanisms within the microcirculation. The expert reviews address issues, such as the role of miRNAs in determining endothelial cell differentiation and lineage commitment, the physiological role of miRNAs as critical modulators of endothelial cell proliferation, apoptosis and in angiogenesis, and their aberrant expression in different vascular disorders. The reviews also explore the prognostic value of miRNAs in cardiovascular disease and how they may serve both as a therapeutic target and clinical biomarker in the future. This cutting edge edition of the journal Microcirculation highlights the progress that has been made in this new and challenging research area.
Original languageEnglish
Pages (from-to)193 - 195
Number of pages3
JournalMicrocirculation
Volume19
Issue number3
DOIs
Publication statusPublished - Apr 2012

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