TY - CHAP
T1 - Spotlight on non-motor symptoms and Covid-19
AU - Rota, Silvia
AU - Boura, Iro
AU - Wan, Yi Min
AU - Lazcano-Ocampo, Claudia
AU - Rodriguez-Violante, Mayela
AU - Antonini, Angelo
AU - Chaudhuri, Kallol Ray
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/1
Y1 - 2022/1
N2 - The Coronavirus Disease 2019 (Covid-19) pandemic has profoundly affected the quality of life (QoL) and health of the general population globally over the past 2 years, with a clear impact on people with Parkinson's Disease (PwP, PD). Non-motor symptoms have been widely acknowledged to hold a vital part in the clinical spectrum of PD, and, although often underrecognized, they significantly contribute to patients' and their caregivers' QoL. Up to now, there have been numerous reports of newly emerging or acutely deteriorating non-motor symptoms in PwP who had been infected by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), while some of these symptoms, like fatigue, pain, depression, anxiety and cognitive impairment, have also been identified as part of the long-COVID syndrome due to their persistent nature. The subjacent mechanisms, mediating the appearance or progression of non-motor symptoms in the context of Covid-19, although probably multifactorial in origin, remain largely unknown. Such mechanisms might be, at least partly, related solely to the viral infection per se or the lifestyle changes imposed during the pandemic, as many of the non-motor symptoms seem to be prevalent even among Covid-19 patients without PD. Here, we summarize the available evidence and implications of Covid-19 in non-motor PD symptoms in the acute and chronic, if applicable, phase of the infection, with a special reference on studies of PwP.
AB - The Coronavirus Disease 2019 (Covid-19) pandemic has profoundly affected the quality of life (QoL) and health of the general population globally over the past 2 years, with a clear impact on people with Parkinson's Disease (PwP, PD). Non-motor symptoms have been widely acknowledged to hold a vital part in the clinical spectrum of PD, and, although often underrecognized, they significantly contribute to patients' and their caregivers' QoL. Up to now, there have been numerous reports of newly emerging or acutely deteriorating non-motor symptoms in PwP who had been infected by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), while some of these symptoms, like fatigue, pain, depression, anxiety and cognitive impairment, have also been identified as part of the long-COVID syndrome due to their persistent nature. The subjacent mechanisms, mediating the appearance or progression of non-motor symptoms in the context of Covid-19, although probably multifactorial in origin, remain largely unknown. Such mechanisms might be, at least partly, related solely to the viral infection per se or the lifestyle changes imposed during the pandemic, as many of the non-motor symptoms seem to be prevalent even among Covid-19 patients without PD. Here, we summarize the available evidence and implications of Covid-19 in non-motor PD symptoms in the acute and chronic, if applicable, phase of the infection, with a special reference on studies of PwP.
KW - Anxiety
KW - Cognition
KW - Covid-19
KW - Depression
KW - Fatigue
KW - Gastrointestinal
KW - Non-motor symptoms
KW - Parkinson's disease
KW - SARS-CoV-2
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=85133738687&partnerID=8YFLogxK
U2 - 10.1016/bs.irn.2022.04.001
DO - 10.1016/bs.irn.2022.04.001
M3 - Chapter
AN - SCOPUS:85133738687
SN - 9780323991735
T3 - International Review of Neurobiology
SP - 103
EP - 133
BT - Covid-19 and Parkinsonism
A2 - Chaudhuri, K Ray
A2 - Rodríguez-Violante, Mayela
A2 - Antonini, Angelo
A2 - Boura, Iro
A2 - Boura, Iro
PB - ACADEMIC PRESS INC
ER -
