Sprouty proteins: multifaceted negative-feed back regulators of receptor tyrosine kinase signaling

TY - JOUR

T1 - Sprouty proteins: multifaceted negative-feed back regulators of receptor tyrosine kinase signaling

AU - Mason, J M

AU - Morrison, D J

AU - Basson, M A

AU - Licht, J D

PY - 2006/1

Y1 - 2006/1

N2 - Receptor tyrosine kinases (RTKs) control a wide variety of processes in multicellular organisms, including proliferation, differentiation, migration and survival. Their activity is tightly controlled through the coordinated action of both positive and negative regulators that function at multiple levels of the signal transduction cascade, and at different time points within the growth-factor-induced response. When this process goes awry, the outcome can be developmental defects and malignancy. Sprouty (Spry) proteins represent a major class of ligand-inducible inhibitors of RTK-dependent signaling pathways. New biochemical and genetic evidence indicates specific roles of the Sprygenes in development and multiple modes of action of the Spry proteins in regulation of the RTK-induced response

AB - Receptor tyrosine kinases (RTKs) control a wide variety of processes in multicellular organisms, including proliferation, differentiation, migration and survival. Their activity is tightly controlled through the coordinated action of both positive and negative regulators that function at multiple levels of the signal transduction cascade, and at different time points within the growth-factor-induced response. When this process goes awry, the outcome can be developmental defects and malignancy. Sprouty (Spry) proteins represent a major class of ligand-inducible inhibitors of RTK-dependent signaling pathways. New biochemical and genetic evidence indicates specific roles of the Sprygenes in development and multiple modes of action of the Spry proteins in regulation of the RTK-induced response

U2 - 10.1016/j.tcb.2005.11.004

DO - 10.1016/j.tcb.2005.11.004

M3 - Literature review

VL - 16

SP - 45

EP - 54

JO - TRENDS IN CELL BIOLOGY

JF - TRENDS IN CELL BIOLOGY

IS - 1

ER -