@article{4a92716e6da34d07bc3a0580b28d9218,
title = "Standard care vs. TRIVEntricular pacing in Heart Failure (STRIVE HF): a prospective multicentre randomized controlled trial of triventricular pacing vs. conventional biventricular pacing in patients with heart failure and intermediate QRS left bundle branch block",
abstract = "Aims To determine whether triventricular (TriV) pacing is feasible and improves CRT response compared to conventional biventricular (BiV) pacing in patients with left bundle branch block (LBBB) and intermediate QRS prolongation (120-150 ms). Methods and results Between October 2015 and November 2019, 99 patients were recruited from 11 UK centres. Ninety-five patients were randomized 1:1 to receive TriV or BiV pacing systems. The primary endpoint was feasibility of TriV pacing. Secondary endpoints assessed symptomatic and remodelling response to CRT. Baseline characteristics were balanced between groups. In the TriV group, 43/46 (93.5%) patients underwent successful implantation vs. 47/49 (95.9%) in the BiV group. Feasibility of maintaining CRT at 6 months was similar in the TriV vs. BiV group (90.0% vs. 97.7%, P = 0.191). All-cause mortality was similar between TriV vs. BiV groups (4.3% vs. 8.2%, P = 0.678). There were no significant differences in echocardiographic LV volumes or clinical composite scores from baseline to 6-month follow-up between groups. Conclusion Implantation of two LV leads to deliver and maintain TriV pacing at 6 months is feasible without significant complications in the majority of patients. There was no evidence that TriV pacing improves CRT response or provides.",
author = "Justin Gould and Simon Claridge and Thomas Jackson and Sieniewicz, {Benjamin J.} and Sidhu, {Baldeep S.} and Bradley Porter and Elliott, {Mark K.} and Vishal Mehta and Steven Niederer and Humra Chadwick and Ravi Kamdar and Shaumik Adhya and Nikhil Patel and Shoaib Hamid and Dominic Rogers and William Nicolson and Chan, {Cheuk F.} and Zachary Whinnett and Francis Murgatroyd and Lambiase, {Pier D.} and Rinaldi, {Christopher A.}",
note = "Funding Information: MicroPort Cardiac Rhythm Management (formerly LivaNova and Sorin) funded but did not take part in the study design, data collection, analysis, interpretation of results, manuscript writing, or the publication strategy. This work was supported by the Wellcome/ Engineering and Physical Sciences Research Council Centre for Medical Engineering (WT203148/Z/16/Z). Funding Information: MicroPort Cardiac Rhythm Management (formerly LivaNova and Sorin) funded but did not take part in the study design, data collection, analysis, interpretation of results, manuscript writing, or the publication strategy. This work was supported by the Wellcome/Engineering and Physical Sciences Research Council Centre for Medical Engineering (WT203148/Z/16/Z). Funding Information: Conflict of interest: J.G., B.P., M.K.E., and V.M. have received fellowship funding from Abbott outside of the submitted work. B.S.S. is funded by an National Institute for Health Research project grant and has received speaker fees from EBR systems outside the submitted work. B.J.S. has received a British Heart Foundation project grant outside of the submitted work. S.N. is supported by EPSRC (EP/ P01268X/1; NS/A000049/1; EP/M012492/1), BHF (PG/15/91/31812; FS/18/27/33543), NIHR (II-LB-1116-20001), and Wellcome Trust (WT203148/Z/16/Z). Z.W. has received speaker fees for MicroPort and Medtronic and is on the advisory board for Medtronic and Abbott. P.D.L. is supported by UCL/UCLH Biomedicine National Institute for Health Research and Barts Biomedical Research Centre and receives fellowship funding, research grants, and speaker fees from Abbott and Boston Scientific. C.A.R. receives research funding and/or consultation fees from Abbott, Medtronic, Boston Scientific, and MicroPort outside of the submitted work. All other authors declared no conflict of interest. Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.",
year = "2022",
doi = "10.1093/europace/euab267",
language = "English",
volume = "24",
pages = "796--806",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press (OUP)",
number = "5",
}