TY - JOUR
T1 - Standardised Methods for Developing Conceptual Frameworks for Placental Disorders of Pregnancy
T2 - Pre-Eclampsia and Stillbirth
AU - PRECISE Network
AU - Elawad, Terteel
AU - Woo Kinshella, Mai Lei
AU - Stokes, Ellie
AU - Pickerill, Kelly
AU - Piagge, Elisa Dalle
AU - Vidler, Marianne
AU - Stanley, Ella
AU - Volvert, Marie Laure
AU - Bone, Jeffrey N.
AU - Elwell, Helen
AU - Mistry, Hiten D.
AU - Mateljan, Violet
AU - Tsigas, Eleni
AU - Filippi, Veronique
AU - von Dadelszen, Peter
AU - Blencowe, Hannah
AU - Magee, Laura A.
N1 - Publisher Copyright:
© 2025 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
PY - 2025
Y1 - 2025
N2 - Background: Risk factors for the placental disorders of pregnancy (pre-eclampsia, fetal growth restriction, preterm birth, and stillbirth) are complex, frequently involving the interplay between clinical factors and wider social and environmental determinants of health. Biomarkers modulate the maternal and fetal responses to biological processes that underlie the development of placental disorders. Objectives: To develop a standardised methodology to assess the importance of, and inter-relationships between, candidate risk factors for the various placental disorders. Search Strategy: Systematic searches were conducted using Medline, Embase, Health Technology Assessments, Database of Abstracts of Reviews of Effects, Cochrane Library databases, Google Scholar, and reference lists of retrieved papers. Selection Criteria: We deployed a hierarchy of reviews, systematic reviews, and cohort studies with at least 1000 participants (100 for biomarker studies), published in the prior decade. Data Collection and Analysis: We assessed the strengths of association and quality of evidence linking risk factors with individual placental outcomes. Conclusions: We have developed a standardised approach to assess the importance and inter-relatedness of putative risk factors for the placental disorders of pregnancy.
AB - Background: Risk factors for the placental disorders of pregnancy (pre-eclampsia, fetal growth restriction, preterm birth, and stillbirth) are complex, frequently involving the interplay between clinical factors and wider social and environmental determinants of health. Biomarkers modulate the maternal and fetal responses to biological processes that underlie the development of placental disorders. Objectives: To develop a standardised methodology to assess the importance of, and inter-relationships between, candidate risk factors for the various placental disorders. Search Strategy: Systematic searches were conducted using Medline, Embase, Health Technology Assessments, Database of Abstracts of Reviews of Effects, Cochrane Library databases, Google Scholar, and reference lists of retrieved papers. Selection Criteria: We deployed a hierarchy of reviews, systematic reviews, and cohort studies with at least 1000 participants (100 for biomarker studies), published in the prior decade. Data Collection and Analysis: We assessed the strengths of association and quality of evidence linking risk factors with individual placental outcomes. Conclusions: We have developed a standardised approach to assess the importance and inter-relatedness of putative risk factors for the placental disorders of pregnancy.
KW - conceptual framework
KW - fetal growth restriction
KW - placental disorders
KW - pre-eclampsia
KW - preterm birth
KW - stillbirth
UR - http://www.scopus.com/inward/record.url?scp=85219198625&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.18083
DO - 10.1111/1471-0528.18083
M3 - Article
AN - SCOPUS:85219198625
SN - 1470-0328
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
ER -
