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Standardizing T-Cell biomarkers in type 1 diabetes: Challenges and recent advances

Research output: Contribution to journalArticle

Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko

Original languageEnglish
Pages (from-to)1366-1379
Number of pages14
JournalDiabetes
Volume68
Issue number7
DOIs
Publication statusPublished - 1 Jan 2019

King's Authors

Abstract

Type 1 diabetes (T1D) results from the progressive destruction of pancreatic b-cells in a process mediated primarily by T lymphocytes. The T1D research community has made dramatic progress in understanding the genetic basis of the disease as well as in the development of standardized autoantibody assays that inform both disease risk and progression. Despite these advances, there remains a paucity of robust and accepted biomarkers that can effectively inform on the activity of T cells during the natural history of the disease or in response to treatment. In this article, we discuss biomarker development and validation efforts for evaluation of T-cell responses in patients with and at risk for T1D as well as emerging technologies. It is expected that with systematic planning and execution of a well-conceived biomarker development pipeline, T-cell-related biomarkers would rapidly accelerate disease progression monitoring efforts and the evaluation of intervention therapies in T1D.

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