Standing Excitation Waves in the Heart Induced by Strong Alternating Electric Fields

R A Gray, O A Mornev, J Jalife, O V Aslanidi, A M Pertsov

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27 Citations (Scopus)

Abstract

We studied the effect of sinusoidal electric fields on cardiac tissue both experimentally and numerically. We found that periodic forcing at 5-20 Hz using voltage applied in the bathing solution could stop the propagation of excitation waves by producing standing waves of membrane depolarization. These patterns were independent of the driving frequency in contrast to classical standing waves. The stimulus strength required for pattern formation was large compared to the excitation threshold. A novel tridomain representation of cardiac tissue was required to reproduce this behavior numerically.
Original languageEnglish
Pages (from-to)168104
JournalPhysical Review Letters
Volume87
Issue number16
DOIs
Publication statusPublished - 2 Oct 2001

Keywords

  • Heart
  • Animals
  • Electromagnetic Fields
  • Kinetics
  • Electrodes
  • Algorithms
  • Membrane Potentials
  • Rabbits

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