Stem cell-based biological tooth repair and regeneration

Research output: Contribution to journalLiterature reviewpeer-review

227 Citations (Scopus)

Abstract

Teeth exhibit limited repair in response to damage, and dental pulp stem cells probably provide a source of cells to replace those damaged and to facilitate repair Stem cells in other parts of the tooth, such as the periodontal ligament and growing roots, play more dynamic roles in tooth function and development Dental stem cells can be obtained with ease, making them an attractive source of autologous stem cells for use in restoring vital pulp tissue removed because of infection, in regeneration of periodontal ligament lost in periodontal disease, and for generation of complete or partial tooth structures to form biological implants As dental stem cells share properties with mesenchymal stem cells there is also considerable interest in their wider potential to treat disorders involving mesenchymal (or indeed non-mesenchymal) cell derivatives, such as in Parkinson's disease
Original languageEnglish
Pages (from-to)715 - 722
Number of pages8
JournalTRENDS IN CELL BIOLOGY
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 2010

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