Abstract
This chapter focuses on the application of stem cells to treat vascular disease such as Atherosclerosis, and discusses the mechanisms of stem cell differentiation. Atherosclerosis is an inflammatory condition of large-and medium-sized muscular arteries and is characterized by endothelial dysfunction that results in delayed or impaired endothelialization. The strategy using endothelial progenitors to repair the endothelium and restore its function is to increase the number of progenitors by transfusing prepared cells derived from the blood or bone marrow. Tissue engineering allows creating replacement structures with stem cells derived from autologous or nonautologous sources. The direct differentiation of mature cells that bypass the pluripotent state during somatic cell reprogramming is enabled, thus accelerating the production of a desired cell type in a direct and more efficient manner. The use of induced luripotent stem cells (iPSCs) or somatic cell programming may generate autologous cells that are genetically compatible with patient tissue.
| Original language | English |
|---|---|
| Title of host publication | Atherosclerosis |
| Subtitle of host publication | Risks, Mechanisms, and Therapies |
| Publisher | WILEY-BLACKWELL |
| Pages | 557-566 |
| Number of pages | 10 |
| ISBN (Electronic) | 9781118828533 |
| ISBN (Print) | 9781118285916 |
| DOIs | |
| Publication status | Published - 27 Mar 2015 |
Keywords
- Atherosclerosis
- Autologous source
- Endothelial dysfunction
- Endothelial progenitors
- Induced luripotent stem cells (iPSCs)
- Nonautologous sources
- Somatic cell reprogramming
- Stem cell therapeutics
- Tissue engineering