Stem/progenitor cells in normal physiology and disease of the pancreas

TY - JOUR

T1 - Stem/progenitor cells in normal physiology and disease of the pancreas

AU - Alvarez Fallas, Mario Enrique

AU - Pedraza-Arevalo, Sergio

AU - Cujba, Ana Maria

AU - Manea, Teodora

AU - Lambert, Christopher

AU - Morrugares, Rosario

AU - Sancho, Rocio

N1 - Funding Information: We thank Dr Catherine Cremona for her valuable comments on the manuscript. This work is supported by King's College London , Wellcome Seed Award in Science ( 207529/Z/17/Z ) and MRC-NIRG ( MR/S000011/1 ) to RS. AMC and TM are supported by Wellcome Trust PhD fellowships ( 203768/Z/16/Z and 108874/B/15/Z ). CL is supported by the MRC-KCL Doctoral Training Partnership in Biomedical Sciences ( MR/N013700/1 ). MAF is funded by MRC-NIRG grant ( MR/S000011/1 ) to RS. SPA is funded by MRC/JDRF grant ( MR/T015470/1 ) to RS. Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Though embryonic pancreas progenitors are well characterised, the existence of stem/progenitor cells in the postnatal mammalian pancreas has been long debated, mainly due to contradicting results on regeneration after injury or disease in mice. Despite these controversies, sequencing advancements combined with lineage tracing and organoid technologies indicate that homeostatic and trigger-induced regenerative responses in mice could occur. The presence of putative progenitor cells in the adult pancreas has been proposed during homeostasis and upon different stress challenges such as inflammation, tissue damage and oncogenic stress. More recently, single cell transcriptomics has revealed a remarkable heterogeneity in all pancreas cell types, with some cells showing the signature of potential progenitors. In this review we provide an overview on embryonic and putative adult pancreas progenitors in homeostasis and disease, with special emphasis on in vitro culture systems and scRNA-seq technology as tools to address the progenitor nature of different pancreatic cells.

AB - Though embryonic pancreas progenitors are well characterised, the existence of stem/progenitor cells in the postnatal mammalian pancreas has been long debated, mainly due to contradicting results on regeneration after injury or disease in mice. Despite these controversies, sequencing advancements combined with lineage tracing and organoid technologies indicate that homeostatic and trigger-induced regenerative responses in mice could occur. The presence of putative progenitor cells in the adult pancreas has been proposed during homeostasis and upon different stress challenges such as inflammation, tissue damage and oncogenic stress. More recently, single cell transcriptomics has revealed a remarkable heterogeneity in all pancreas cell types, with some cells showing the signature of potential progenitors. In this review we provide an overview on embryonic and putative adult pancreas progenitors in homeostasis and disease, with special emphasis on in vitro culture systems and scRNA-seq technology as tools to address the progenitor nature of different pancreatic cells.

KW - Cell fate decisions

KW - Pancreas progenitors

KW - scRNA-seq

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85115751593&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2021.111459

DO - 10.1016/j.mce.2021.111459

M3 - Article

AN - SCOPUS:85115751593

SN - 0303-7207

VL - 538

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

M1 - 111459

ER -