King's College London

Research portal

Stereotactic radiotherapy for wet age-related macular degeneration: Current perspectives

Research output: Contribution to journalArticle

James E Neffendorf, Timothy Jackson

Original languageEnglish
Pages (from-to)1829-1834
Number of pages6
JournalClinical ophthalmology (Auckland, N.Z.)
Volume9
DOIs
Publication statusPublished - 28 Sep 2015

Documents

  • neffendorf and jackson

    neffendorf_and_jackson.pdf, 1.1 MB, application/pdf

    25/03/2016

    Final published version

    CC BY-NC

King's Authors

Abstract

Neovascular age-related macular degeneration is a leading cause of blindness in the developed world. Currently, the treatment of choice is intravitreal injections of anti-VEGF medications. These require frequent dosing, up to monthly, and impose a substantial burden on patients and the health economy. Ionizing radiation was proposed as a possible treatment for age-related macular degeneration due to its anti-inflammatory and anti-fibrotic properties. Stereotactic radiotherapy is an outpatient-based radiotherapy platform that provides stereotactic application of low energy X-ray to the retina in three highly collimated beams that cross the inferior sclera to overlap at the macula. A randomized, double-masked, sham-controlled trial of 230 patients (INTREPID) showed that a single dose of stereotactic radiotherapy significantly reduces the number of intravitreal anti-VEGF injections needed over 2 years. A larger randomized controlled trial (STAR) is underway.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454