Strategies for Improving Randomized Trial Evidence for Treatment of Bipolar Disorder

Aysegül Yildiz; Juan Undurraga; Eduard Vieta; Dina Popovic; Sarah Christina Wooderson; Allan Young

doi:10.1093/med/9780199300532.003.0042

Strategies for Improving Randomized Trial Evidence for Treatment of Bipolar Disorder

Aysegül Yildiz, Juan Undurraga, Eduard Vieta, Dina Popovic, Sarah Christina Wooderson, Allan Young

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Treatment of bipolar disorder involves acute and maintenance phases with special considerations for manic and depressive episodes. As such, accumulated randomized controlled trials (RCTs) based evidence for treatment options of acute bipolar depression, mania, or maintenance phases require independent considerations. This chapter reviews methodological obstacles that are impeding progress in the development of therapeutic strategies for treatment of this serious illness and recommends strategies aimed at aiding improvement of future trials. Challenges encountered in design and conduct of the RCTs of bipolar depression, mania, and prophylaxis are considered independently. In each of these trial sets, limitations of existing evidence and strategies for their improvement are discussed.

Original language	English
Title of host publication	The Bipolar Book
Subtitle of host publication	History, Neurobiology, and Treatment
Editors	Aysegul Yildiz, Pedro Ruiz, Charles Nemeroff
Publisher	Oxford Univerity Press; Oxford
ISBN (Print)	9780199300532
DOIs	https://doi.org/10.1093/med/9780199300532.003.0042
Publication status	Published - 9 Jul 2015

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title = "Strategies for Improving Randomized Trial Evidence for Treatment of Bipolar Disorder",

abstract = "Treatment of bipolar disorder involves acute and maintenance phases with special considerations for manic and depressive episodes. As such, accumulated randomized controlled trials (RCTs) based evidence for treatment options of acute bipolar depression, mania, or maintenance phases require independent considerations. This chapter reviews methodological obstacles that are impeding progress in the development of therapeutic strategies for treatment of this serious illness and recommends strategies aimed at aiding improvement of future trials. Challenges encountered in design and conduct of the RCTs of bipolar depression, mania, and prophylaxis are considered independently. In each of these trial sets, limitations of existing evidence and strategies for their improvement are discussed.",

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Strategies for Improving Randomized Trial Evidence for Treatment of Bipolar Disorder. / Yildiz, Aysegül; Undurraga, Juan; Vieta, Eduard et al.
The Bipolar Book: History, Neurobiology, and Treatment. ed. / Aysegul Yildiz; Pedro Ruiz; Charles Nemeroff. Oxford Univerity Press; Oxford, 2015. 42.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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T1 - Strategies for Improving Randomized Trial Evidence for Treatment of Bipolar Disorder

AU - Yildiz, Aysegül

AU - Undurraga, Juan

AU - Vieta, Eduard

AU - Popovic, Dina

AU - Wooderson, Sarah Christina

AU - Young, Allan

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AB - Treatment of bipolar disorder involves acute and maintenance phases with special considerations for manic and depressive episodes. As such, accumulated randomized controlled trials (RCTs) based evidence for treatment options of acute bipolar depression, mania, or maintenance phases require independent considerations. This chapter reviews methodological obstacles that are impeding progress in the development of therapeutic strategies for treatment of this serious illness and recommends strategies aimed at aiding improvement of future trials. Challenges encountered in design and conduct of the RCTs of bipolar depression, mania, and prophylaxis are considered independently. In each of these trial sets, limitations of existing evidence and strategies for their improvement are discussed.

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DO - 10.1093/med/9780199300532.003.0042

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A2 - Yildiz, Aysegul

A2 - Ruiz, Pedro

A2 - Nemeroff, Charles

PB - Oxford Univerity Press; Oxford

ER -

Strategies for Improving Randomized Trial Evidence for Treatment of Bipolar Disorder

Abstract

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