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Stratifying cancer therapies by molecular interactions and imaging

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationMechanisms of Molecular Carcinogenesis
PublisherSpringer International Publishing Switzerland
Pages315-358
Number of pages44
Volume2
ISBN (Electronic)9783319536613
ISBN (Print)9783319536606
DOIs
StateE-pub ahead of print - 23 May 2017

King's Authors

Abstract

Accumulated knowledge generated by years of fundamental research and more recently the implementation of high-throughput sequencing analysis and genomic technologies have led to the identification of novel molecular events that are critical oncogenic drivers amenable to targeted therapy. As a result, in the past decade, we have observed the introduction of molecularly targeted therapies for the treatment of cancers within clinical trials that have then subsequently gained approval for use in routine clinical practice. Some of these agents have demonstrated dramatic efficacies, not previously observed in the treatment of metastatic cancers, such as malignant melanoma, non-small cell lung cancer (NSCLC), colorectal cancer and breast cancer.

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