Stress del reticolo endoplasmatico nella malattia renale cronica. Nuovi approcci clinico translazionali dal laboratorio al letto del paziente

Carlo Alberto Ricciardi; Luigi Gnudi

Stress del reticolo endoplasmatico nella malattia renale cronica. Nuovi approcci clinico translazionali dal laboratorio al letto del paziente

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.

Original language	Italian
Pages (from-to)	9-18
Number of pages	10
Journal	Giornale Italiano di Nefrologia
Volume	36
Issue number	6
Publication status	Published - 1 Nov 2019

Keywords

chronic kidney disease
endoplasmic reticulum
reticulon
unfolded protein response

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Stress del reticolo endoplasmatico nella malattia renale cronica. Nuovi approcci clinico translazionali dal laboratorio al letto del paziente",

abstract = "The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.",

keywords = "chronic kidney disease, endoplasmic reticulum, reticulon, unfolded protein response",

author = "Ricciardi, {Carlo Alberto} and Luigi Gnudi",

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year = "2019",

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TY - JOUR

T1 - Stress del reticolo endoplasmatico nella malattia renale cronica. Nuovi approcci clinico translazionali dal laboratorio al letto del paziente

AU - Ricciardi, Carlo Alberto

AU - Gnudi, Luigi

PY - 2019/11/1

Y1 - 2019/11/1

N2 - The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.

AB - The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.

KW - chronic kidney disease

KW - endoplasmic reticulum

KW - reticulon

KW - unfolded protein response

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M3 - Review article

AN - SCOPUS:85152416686

SN - 0393-5590

VL - 36

SP - 9

EP - 18

JO - Giornale Italiano di Nefrologia

JF - Giornale Italiano di Nefrologia

IS - 6

ER -

Stress del reticolo endoplasmatico nella malattia renale cronica. Nuovi approcci clinico translazionali dal laboratorio al letto del paziente

Abstract

Keywords

UN SDGs

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