Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP

Robert Keers; Rudolf Uher; Bhanu Gupta; Marcella Rietschel; Thomas G Schulze; Joanna Hauser; Maria Skibinska; Neven Henigsberg; Petra Kalember; Wolfgang Maier; Astrid Zobel; Ole Mors; Ann S Kristensen; Dejan Kozel; Caterina Giovannini; Julien Mendlewicz; Sudhir Kumar; Peter McGuffin; Anne E Farmer; Katherine J Aitchison

doi:10.1016/j.jad.2010.06.011

Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP

Robert Keers, Rudolf Uher, Bhanu Gupta, Marcella Rietschel, Thomas G Schulze, Joanna Hauser, Maria Skibinska, Neven Henigsberg, Petra Kalember, Wolfgang Maier, Astrid Zobel, Ole Mors, Ann S Kristensen, Dejan Kozel, Caterina Giovannini, Julien Mendlewicz, Sudhir Kumar, Peter McGuffin, Anne E Farmer, Katherine J Aitchison

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Background: The occurrence of stressful life events (SLEs) has been shown to predict response to antidepressants; however, results are inconsistent. There is some evidence to suggest that SLEs prior to treatment are associated with greater cognitive symptoms at baseline and may therefore predict changes in these symptoms specifically. Methods: GENDEP, a prospective part-randomised pharmacogenomics trial, collected longitudinal data on the symptoms of patients with major depression treated with either a selective serotonin reuptake inhibitor (SSRI, escitalopram) or a tricyclic antidepressant (TCA, nortriptyline). Data on life events experienced in the 6 months preceding treatment measured using the List of Threatening Experiences Questionnaire (LTE-Q) were available for 728 participants. Results: Both the occurrence and number of SLEs were associated with greater cognitive but not mood or neurovegetative symptoms prior to treatment. Those who reported SLEs also experienced a greater decline in cognitive symptoms during treatment with escitalopram. but not with nortriptyline. Limitations: Life events were measured retrospectively using a self-report checklist and are therefore subject to a number of biases especially in the context of depressive illness. Conclusions: These findings are in line with cognitive theories of depression and suggest that symptomatic heterogeneity may have contributed to inconsistencies in studies reported to date. Our results also tentatively suggest a clinically relevant drug specific effect of SLEs. Specifically, those reporting stress may benefit more from treatment with SSRIs than TCAs. (C) 2010 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	337 - 342
Number of pages	6
Journal	Journal of Affective Disorders
Volume	127
Issue number	1-3
DOIs	https://doi.org/10.1016/j.jad.2010.06.011
Publication status	Published - Dec 2010

Keywords

Adult
Affect
Antidepressive Agents, Second-Generation
Antidepressive Agents, Tricyclic
Citalopram
Cognition Disorders
Depressive Disorder, Major
Female
Humans
Life Change Events
Longitudinal Studies
Male
Mental Status Schedule
Middle Aged
Nortriptyline
Pharmacogenetics

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10.1016/j.jad.2010.06.011

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Keers, R., Uher, R., Gupta, B., Rietschel, M., Schulze, T. G., Hauser, J., Skibinska, M., Henigsberg, N., Kalember, P., Maier, W., Zobel, A., Mors, O., Kristensen, A. S., Kozel, D., Giovannini, C., Mendlewicz, J., Kumar, S., McGuffin, P., Farmer, A. E., & Aitchison, K. J. (2010). Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP. Journal of Affective Disorders, 127(1-3), 337 - 342. https://doi.org/10.1016/j.jad.2010.06.011

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title = "Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP",

abstract = "Background: The occurrence of stressful life events (SLEs) has been shown to predict response to antidepressants; however, results are inconsistent. There is some evidence to suggest that SLEs prior to treatment are associated with greater cognitive symptoms at baseline and may therefore predict changes in these symptoms specifically. Methods: GENDEP, a prospective part-randomised pharmacogenomics trial, collected longitudinal data on the symptoms of patients with major depression treated with either a selective serotonin reuptake inhibitor (SSRI, escitalopram) or a tricyclic antidepressant (TCA, nortriptyline). Data on life events experienced in the 6 months preceding treatment measured using the List of Threatening Experiences Questionnaire (LTE-Q) were available for 728 participants. Results: Both the occurrence and number of SLEs were associated with greater cognitive but not mood or neurovegetative symptoms prior to treatment. Those who reported SLEs also experienced a greater decline in cognitive symptoms during treatment with escitalopram. but not with nortriptyline. Limitations: Life events were measured retrospectively using a self-report checklist and are therefore subject to a number of biases especially in the context of depressive illness. Conclusions: These findings are in line with cognitive theories of depression and suggest that symptomatic heterogeneity may have contributed to inconsistencies in studies reported to date. Our results also tentatively suggest a clinically relevant drug specific effect of SLEs. Specifically, those reporting stress may benefit more from treatment with SSRIs than TCAs. (C) 2010 Elsevier B.V. All rights reserved.",

keywords = "Adult, Affect, Antidepressive Agents, Second-Generation, Antidepressive Agents, Tricyclic, Citalopram, Cognition Disorders, Depressive Disorder, Major, Female, Humans, Life Change Events, Longitudinal Studies, Male, Mental Status Schedule, Middle Aged, Nortriptyline, Pharmacogenetics",

author = "Robert Keers and Rudolf Uher and Bhanu Gupta and Marcella Rietschel and Schulze, {Thomas G} and Joanna Hauser and Maria Skibinska and Neven Henigsberg and Petra Kalember and Wolfgang Maier and Astrid Zobel and Ole Mors and Kristensen, {Ann S} and Dejan Kozel and Caterina Giovannini and Julien Mendlewicz and Sudhir Kumar and Peter McGuffin and Farmer, {Anne E} and Aitchison, {Katherine J}",

year = "2010",

month = dec,

doi = "10.1016/j.jad.2010.06.011",

language = "English",

volume = "127",

pages = "337 -- 342",

journal = "Journal of Affective Disorders",

issn = "1573-2517",

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Keers, R , Uher, R, Gupta, B, Rietschel, M, Schulze, TG, Hauser, J, Skibinska, M, Henigsberg, N, Kalember, P, Maier, W, Zobel, A, Mors, O, Kristensen, AS, Kozel, D, Giovannini, C, Mendlewicz, J, Kumar, S, McGuffin, P , Farmer, AE & Aitchison, KJ 2010, 'Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP', Journal of Affective Disorders, vol. 127, no. 1-3, pp. 337 - 342. https://doi.org/10.1016/j.jad.2010.06.011

TY - JOUR

T1 - Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP

AU - Keers, Robert

AU - Uher, Rudolf

AU - Gupta, Bhanu

AU - Rietschel, Marcella

AU - Schulze, Thomas G

AU - Hauser, Joanna

AU - Skibinska, Maria

AU - Henigsberg, Neven

AU - Kalember, Petra

AU - Maier, Wolfgang

AU - Zobel, Astrid

AU - Mors, Ole

AU - Kristensen, Ann S

AU - Kozel, Dejan

AU - Giovannini, Caterina

AU - Mendlewicz, Julien

AU - Kumar, Sudhir

AU - McGuffin, Peter

AU - Farmer, Anne E

AU - Aitchison, Katherine J

PY - 2010/12

Y1 - 2010/12

N2 - Background: The occurrence of stressful life events (SLEs) has been shown to predict response to antidepressants; however, results are inconsistent. There is some evidence to suggest that SLEs prior to treatment are associated with greater cognitive symptoms at baseline and may therefore predict changes in these symptoms specifically. Methods: GENDEP, a prospective part-randomised pharmacogenomics trial, collected longitudinal data on the symptoms of patients with major depression treated with either a selective serotonin reuptake inhibitor (SSRI, escitalopram) or a tricyclic antidepressant (TCA, nortriptyline). Data on life events experienced in the 6 months preceding treatment measured using the List of Threatening Experiences Questionnaire (LTE-Q) were available for 728 participants. Results: Both the occurrence and number of SLEs were associated with greater cognitive but not mood or neurovegetative symptoms prior to treatment. Those who reported SLEs also experienced a greater decline in cognitive symptoms during treatment with escitalopram. but not with nortriptyline. Limitations: Life events were measured retrospectively using a self-report checklist and are therefore subject to a number of biases especially in the context of depressive illness. Conclusions: These findings are in line with cognitive theories of depression and suggest that symptomatic heterogeneity may have contributed to inconsistencies in studies reported to date. Our results also tentatively suggest a clinically relevant drug specific effect of SLEs. Specifically, those reporting stress may benefit more from treatment with SSRIs than TCAs. (C) 2010 Elsevier B.V. All rights reserved.

AB - Background: The occurrence of stressful life events (SLEs) has been shown to predict response to antidepressants; however, results are inconsistent. There is some evidence to suggest that SLEs prior to treatment are associated with greater cognitive symptoms at baseline and may therefore predict changes in these symptoms specifically. Methods: GENDEP, a prospective part-randomised pharmacogenomics trial, collected longitudinal data on the symptoms of patients with major depression treated with either a selective serotonin reuptake inhibitor (SSRI, escitalopram) or a tricyclic antidepressant (TCA, nortriptyline). Data on life events experienced in the 6 months preceding treatment measured using the List of Threatening Experiences Questionnaire (LTE-Q) were available for 728 participants. Results: Both the occurrence and number of SLEs were associated with greater cognitive but not mood or neurovegetative symptoms prior to treatment. Those who reported SLEs also experienced a greater decline in cognitive symptoms during treatment with escitalopram. but not with nortriptyline. Limitations: Life events were measured retrospectively using a self-report checklist and are therefore subject to a number of biases especially in the context of depressive illness. Conclusions: These findings are in line with cognitive theories of depression and suggest that symptomatic heterogeneity may have contributed to inconsistencies in studies reported to date. Our results also tentatively suggest a clinically relevant drug specific effect of SLEs. Specifically, those reporting stress may benefit more from treatment with SSRIs than TCAs. (C) 2010 Elsevier B.V. All rights reserved.

KW - Adult

KW - Affect

KW - Antidepressive Agents, Second-Generation

KW - Antidepressive Agents, Tricyclic

KW - Citalopram

KW - Cognition Disorders

KW - Depressive Disorder, Major

KW - Female

KW - Humans

KW - Life Change Events

KW - Longitudinal Studies

KW - Male

KW - Mental Status Schedule

KW - Middle Aged

KW - Nortriptyline

KW - Pharmacogenetics

U2 - 10.1016/j.jad.2010.06.011

DO - 10.1016/j.jad.2010.06.011

M3 - Article

C2 - 20609482

SN - 1573-2517

VL - 127

SP - 337

EP - 342

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1-3

ER -

Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP

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Keywords

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