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STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials

Research output: Contribution to journalArticle

A. Pels, L. C. Kenny, Z. Alfirevic, P. N. Baker, Peter von Dadelszen, C. Gluud, C. T. Kariya, B. W. Mol, A. T. Papageorghiou, A. G. van Wassenaer-Leemhuis, W. Ganzevoort, K. M. Groom, STRIDER Consortium

Original languageEnglish
Pages (from-to)440
Number of pages1
JournalBMC Pregnancy and Childbirth
Volume17
Issue number1
DOIs
Publication statusPublished - 28 Dec 2017

Documents

  • STRIDER (Sildenafil TheRapy in_PELS_Published28December2017_GOLD VoR (CC BY)

    STRIDER_Sildenafil_TheRapy_in_PELS_Published28December2017_GOLD_VoR_CC_BY_.pdf, 396 KB, application/pdf

    10/01/2018

    Final published version

    CC BY

    © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
    International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
    reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
    the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
    (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

King's Authors

Abstract

Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis.

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