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STRIDER: Sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction – a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis

Research output: Contribution to journalArticle

Wessel Ganzevoort, Zarko Alfirevic, Peter von Dadelszen, Louise Kenny, Aris Papageorghiou, Aleid van Wassenaer-Leemhuis, Christian Gluud, Ben Willem Mol, Philip N. Baker

Original languageEnglish
Pages (from-to)23
Number of pages1
JournalSystematic Reviews
Issue number1
Publication statusPublished - 11 Mar 2014


  • STRIDER Sildenafil therapy in_GANZEVOORT_Published11March2014_GOLD VoR (CC BY)

    STRIDER_Sildenafil_therapy_in_GANZEVOORT_Published11March2014_GOLD_VoR_CC_BY_.pdf, 325 KB, application/pdf


    Final published version

    CC BY

    © 2014 Ganzevoort et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the
    Creative Commons Attribution License (, which permits unrestricted use,
    distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public
    Domain Dedication waiver ( applies to the data made available in this
    article, unless otherwise stated.

King's Authors


In pregnancies complicated by early-onset extreme fetal growth restriction, there is a high risk of preterm birth and an overall dismal fetal prognosis. Sildenafil has been suggested to improve this prognosis. The first aim of this review is to assess whether sildenafil benefits or harms these babies. The second aim is to analyse if these effects are modified in a clinically meaningful way by factors related to the women or the trial protocol.

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