Strontium kinetics in metastasized prostatic carcinoma: a comparison with the predictions of impulse response function analysis

G M Blake; M A Zivanovic; J M Gray

Strontium kinetics in metastasized prostatic carcinoma: a comparison with the predictions of impulse response function analysis

G M Blake, M A Zivanovic, J M Gray

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Amongst patients referred for 89Sr palliation of disseminated prostatic carcinoma, we have found wide variations in extent of skeletal metastatic disease and in strontium renal plasma clearance. A numerical technique using impulse response function analysis is reviewed which enables the effect of such variations on the total body, plasma and metastatic strontium retention functions to be calculated. The prediction of the model are compared with kinetic data from patients presenting for radiostrontium therapy, and correlations that have important implications for 89Sr dosimetric studies are confirmed. The simplest kinetic data required to allow for these effects in studies of dose-response and haematological toxicity following radio-strontium treatment are discussed and attention is drawn to a small group of patients who may form a significant exception to the general model.

Original language	English
Pages (from-to)	909-19
Number of pages	11
Journal	Nuclear Medicine Communications
Volume	8
Issue number	11
Publication status	Published - 1987

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title = "Strontium kinetics in metastasized prostatic carcinoma: a comparison with the predictions of impulse response function analysis",

abstract = "Amongst patients referred for 89Sr palliation of disseminated prostatic carcinoma, we have found wide variations in extent of skeletal metastatic disease and in strontium renal plasma clearance. A numerical technique using impulse response function analysis is reviewed which enables the effect of such variations on the total body, plasma and metastatic strontium retention functions to be calculated. The prediction of the model are compared with kinetic data from patients presenting for radiostrontium therapy, and correlations that have important implications for 89Sr dosimetric studies are confirmed. The simplest kinetic data required to allow for these effects in studies of dose-response and haematological toxicity following radio-strontium treatment are discussed and attention is drawn to a small group of patients who may form a significant exception to the general model.",

author = "Blake, {G M} and Zivanovic, {M A} and Gray, {J M}",

year = "1987",

language = "English",

volume = "8",

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journal = "Nuclear Medicine Communications",

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T1 - Strontium kinetics in metastasized prostatic carcinoma

T2 - a comparison with the predictions of impulse response function analysis

AU - Blake, G M

AU - Zivanovic, M A

AU - Gray, J M

PY - 1987

Y1 - 1987

N2 - Amongst patients referred for 89Sr palliation of disseminated prostatic carcinoma, we have found wide variations in extent of skeletal metastatic disease and in strontium renal plasma clearance. A numerical technique using impulse response function analysis is reviewed which enables the effect of such variations on the total body, plasma and metastatic strontium retention functions to be calculated. The prediction of the model are compared with kinetic data from patients presenting for radiostrontium therapy, and correlations that have important implications for 89Sr dosimetric studies are confirmed. The simplest kinetic data required to allow for these effects in studies of dose-response and haematological toxicity following radio-strontium treatment are discussed and attention is drawn to a small group of patients who may form a significant exception to the general model.

AB - Amongst patients referred for 89Sr palliation of disseminated prostatic carcinoma, we have found wide variations in extent of skeletal metastatic disease and in strontium renal plasma clearance. A numerical technique using impulse response function analysis is reviewed which enables the effect of such variations on the total body, plasma and metastatic strontium retention functions to be calculated. The prediction of the model are compared with kinetic data from patients presenting for radiostrontium therapy, and correlations that have important implications for 89Sr dosimetric studies are confirmed. The simplest kinetic data required to allow for these effects in studies of dose-response and haematological toxicity following radio-strontium treatment are discussed and attention is drawn to a small group of patients who may form a significant exception to the general model.

M3 - Article

C2 - 3441327

SN - 0143-3636

VL - 8

SP - 909

EP - 919

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 11

ER -

Strontium kinetics in metastasized prostatic carcinoma: a comparison with the predictions of impulse response function analysis

Abstract

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