Structural Analysis of Bacillus subtilis Sigma Factors

Katherine M. Collins, Nicola J. Evans, James H. Torpey, Jonathon M. Harris, Bethany A. Haynes, Amy H. Camp, Rivka L. Isaacson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Bacteria use an array of sigma factors to regulate gene expression during different stages of their life cycles. Full-length, atomic-level structures of sigma factors have been challenging to obtain experimentally as a result of their many regions of intrinsic disorder. AlphaFold has now supplied plausible full-length models for most sigma factors. Here we discuss the current understanding of the structures and functions of sigma factors in the model organism, Bacillus subtilis, and present an X-ray crystal structure of a region of B. subtilis SigE, a sigma factor that plays a critical role in the developmental process of spore formation.

Original languageEnglish
Article number1077
Issue number4
Publication statusPublished - 20 Apr 2023


  • Alphafold
  • Bacillus subtilis
  • SigE
  • sigma factor
  • sporulation
  • structure
  • X-ray crystallography


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