Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Aman Iqbal; Ian. J. Clifton; Rasheduzzaman Chowdhury; David Ivison; Carmen Domene; Christopher J. Schofield

doi:10.1039/c1ob05554b

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Aman Iqbal, Ian. J. Clifton, Rasheduzzaman Chowdhury, David Ivison, Carmen Domene, Christopher J. Schofield^*

^*Corresponding author for this work

Chemistry

University of Oxford

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.

Original language	English
Pages (from-to)	6219-6225
Number of pages	7
Journal	Organic & biomolecular chemistry
Volume	9
Issue number	18
Early online date	28 Jul 2011
DOIs	https://doi.org/10.1039/c1ob05554b
Publication status	Published - 21 Sept 2011

Keywords

SERINE-PROTEASE CATALYSIS
ACYL-ENZYME COMPLEX
CRYSTAL-STRUCTURE
GENE-CLUSTER
ACETYLTRANSFERASE
INTERMEDIATE
MECHANISM

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title = "Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates",

abstract = "Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.",

keywords = "SERINE-PROTEASE CATALYSIS, ACYL-ENZYME COMPLEX, CRYSTAL-STRUCTURE, GENE-CLUSTER, ACETYLTRANSFERASE, INTERMEDIATE, MECHANISM",

author = "Aman Iqbal and Clifton, {Ian. J.} and Rasheduzzaman Chowdhury and David Ivison and Carmen Domene and Schofield, {Christopher J.}",

year = "2011",

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doi = "10.1039/c1ob05554b",

language = "English",

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TY - JOUR

T1 - Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

AU - Iqbal, Aman

AU - Clifton, Ian. J.

AU - Chowdhury, Rasheduzzaman

AU - Ivison, David

AU - Domene, Carmen

AU - Schofield, Christopher J.

PY - 2011/9/21

Y1 - 2011/9/21

N2 - Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.

AB - Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.

KW - SERINE-PROTEASE CATALYSIS

KW - ACYL-ENZYME COMPLEX

KW - CRYSTAL-STRUCTURE

KW - GENE-CLUSTER

KW - ACETYLTRANSFERASE

KW - INTERMEDIATE

KW - MECHANISM

U2 - 10.1039/c1ob05554b

DO - 10.1039/c1ob05554b

M3 - Article

SN - 1477-0520

VL - 9

SP - 6219

EP - 6225

JO - Organic & biomolecular chemistry

JF - Organic & biomolecular chemistry

IS - 18

ER -

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Abstract

Keywords

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