Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: An alternative concept in reconstruction of spinal cord circuits

Nicholas D. James; Maria Angéria; Elizabeth J. Bradbury; Peter Damberg; Stephen B. McMahon; Mårten Risling; Thomas P. Carlstedt

doi:10.3389/fneur.2017.00358

Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: An alternative concept in reconstruction of spinal cord circuits

Nicholas D. James^*, Maria Angéria, Elizabeth J. Bradbury, Peter Damberg, Stephen B. McMahon, Mårten Risling, Thomas P. Carlstedt

^*Corresponding author for this work

Wolfson SPaRC

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Abstract

In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory function. The dorsal root ganglia (DRG) containing the primary sensory nerve cells had been surgically removed in order for secondary or spinal cord sensory neurons to extend into the periphery and replace the deleted DRG neurons. The present experimental study uses a rat injury model first to corroborate the clinical finding of a re-established spinal reflex arch, and second, to elucidate some of the potential mechanisms underlying these findings by means of morphological, immunohistochemical, and electrophysiological assessments. Our findings indicate that, after spinal cord surgery, the central nervous system sensory system could replace the traumatically detached original peripheral sensory connections through new neurite growth from dendrites.

Original language	English
Article number	358
Journal	Frontiers in Neurology
Volume	8
Issue number	JUL
DOIs	https://doi.org/10.3389/fneur.2017.00358
Publication status	Published - 24 Jul 2017

Keywords

Avulsion injury
Electrophysiology
Plasticity
Proprioception
Sensory neurons

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Structural and Functional Substitution_JAMES_Published24July2017_GOLD VoR (CC BY)Final published version, 1.88 MBLicence: CC BY

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James, N. D., Angéria, M., Bradbury, E. J., Damberg, P., McMahon, S. B., Risling, M., & Carlstedt, T. P. (2017). Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: An alternative concept in reconstruction of spinal cord circuits. Frontiers in Neurology, 8(JUL), Article 358. https://doi.org/10.3389/fneur.2017.00358

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abstract = "In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory function. The dorsal root ganglia (DRG) containing the primary sensory nerve cells had been surgically removed in order for secondary or spinal cord sensory neurons to extend into the periphery and replace the deleted DRG neurons. The present experimental study uses a rat injury model first to corroborate the clinical finding of a re-established spinal reflex arch, and second, to elucidate some of the potential mechanisms underlying these findings by means of morphological, immunohistochemical, and electrophysiological assessments. Our findings indicate that, after spinal cord surgery, the central nervous system sensory system could replace the traumatically detached original peripheral sensory connections through new neurite growth from dendrites.",

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James, ND, Angéria, M, Bradbury, EJ, Damberg, P, McMahon, SB, Risling, M & Carlstedt, TP 2017, 'Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: An alternative concept in reconstruction of spinal cord circuits', Frontiers in Neurology, vol. 8, no. JUL, 358. https://doi.org/10.3389/fneur.2017.00358

Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: An alternative concept in reconstruction of spinal cord circuits. / James, Nicholas D.; Angéria, Maria; Bradbury, Elizabeth J. et al.
In: Frontiers in Neurology, Vol. 8, No. JUL, 358, 24.07.2017.

Research output: Contribution to journal › Article › peer-review

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AU - Carlstedt, Thomas P.

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Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: An alternative concept in reconstruction of spinal cord circuits

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