Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

Giuseppina Mariano; Rebecca J Farthing; Shamar L M Lale-Farjat; Julien R C Bergeron

doi:10.3389/fmolb.2020.605236

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

Giuseppina Mariano, Rebecca J Farthing, Shamar L M Lale-Farjat, Julien R C Bergeron

Research output: Contribution to journal › Review article › peer-review

173 Citations (Scopus)

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral infection, in order to develop a vaccine and therapeutic approaches. In particular, structural studies have allowed to comprehend the molecular basis underlying the role of many of the SARS-CoV-2 proteins, and to make rapid progress towards treatment and preventive therapeutics. Despite the great advances that have been provided by these studies, many knowledge gaps on the biology and molecular basis of SARS-CoV-2 infection still remain. Filling these gaps will be the key to tackle this pandemic, through development of effective treatments and specific vaccination strategies.

Original language	English
Pages (from-to)	605236
Journal	Frontiers in Molecular Biosciences
Volume	7
DOIs	https://doi.org/10.3389/fmolb.2020.605236
Publication status	Published - 2020

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10.3389/fmolb.2020.605236

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title = "Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral infection, in order to develop a vaccine and therapeutic approaches. In particular, structural studies have allowed to comprehend the molecular basis underlying the role of many of the SARS-CoV-2 proteins, and to make rapid progress towards treatment and preventive therapeutics. Despite the great advances that have been provided by these studies, many knowledge gaps on the biology and molecular basis of SARS-CoV-2 infection still remain. Filling these gaps will be the key to tackle this pandemic, through development of effective treatments and specific vaccination strategies.",

author = "Giuseppina Mariano and Farthing, {Rebecca J} and Lale-Farjat, {Shamar L M} and Bergeron, {Julien R C}",

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doi = "10.3389/fmolb.2020.605236",

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T1 - Structural Characterization of SARS-CoV-2

T2 - Where We Are, and Where We Need to Be

AU - Mariano, Giuseppina

AU - Farthing, Rebecca J

AU - Lale-Farjat, Shamar L M

AU - Bergeron, Julien R C

PY - 2020

Y1 - 2020

N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral infection, in order to develop a vaccine and therapeutic approaches. In particular, structural studies have allowed to comprehend the molecular basis underlying the role of many of the SARS-CoV-2 proteins, and to make rapid progress towards treatment and preventive therapeutics. Despite the great advances that have been provided by these studies, many knowledge gaps on the biology and molecular basis of SARS-CoV-2 infection still remain. Filling these gaps will be the key to tackle this pandemic, through development of effective treatments and specific vaccination strategies.

AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral infection, in order to develop a vaccine and therapeutic approaches. In particular, structural studies have allowed to comprehend the molecular basis underlying the role of many of the SARS-CoV-2 proteins, and to make rapid progress towards treatment and preventive therapeutics. Despite the great advances that have been provided by these studies, many knowledge gaps on the biology and molecular basis of SARS-CoV-2 infection still remain. Filling these gaps will be the key to tackle this pandemic, through development of effective treatments and specific vaccination strategies.

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DO - 10.3389/fmolb.2020.605236

M3 - Review article

C2 - 33392262

SN - 2296-889X

VL - 7

SP - 605236

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

ER -

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

Abstract

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