Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses

TY - JOUR

T1 - Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses

AU - Burke, David Francis

N1 - Publisher Copyright: © 2023 by the author.

PY - 2023/4/19

Y1 - 2023/4/19

N2 - The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape. Amino acid changes at only seven positions near the receptor binding site of the surface hemagglutinin protein have been shown to be responsible for the major antigenic changes for over forty years. Experimental structures of HA are now available for the majority of the observed antigenic clusters of A/H3N2. An analysis of the HA structures of these viruses reveals the likely consequences of these mutations on the structure of HA and thus, provides a structural basis for the antigenic changes seen in human influenza viruses.

AB - The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape. Amino acid changes at only seven positions near the receptor binding site of the surface hemagglutinin protein have been shown to be responsible for the major antigenic changes for over forty years. Experimental structures of HA are now available for the majority of the observed antigenic clusters of A/H3N2. An analysis of the HA structures of these viruses reveals the likely consequences of these mutations on the structure of HA and thus, provides a structural basis for the antigenic changes seen in human influenza viruses.

KW - antigenic

KW - hemagglutinin

KW - influenza

KW - protein structure

UR - http://www.scopus.com/inward/record.url?scp=85156218705&partnerID=8YFLogxK

U2 - 10.3390/v15041008

DO - 10.3390/v15041008

M3 - Article

C2 - 37112987

AN - SCOPUS:85156218705

SN - 1999-4915

VL - 15

JO - Viruses

JF - Viruses

IS - 4

M1 - 1008

ER -