Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis

André Zugman; Idaiane Assunção; Gilson Vieira; Ary Gadelha; Thomas P. White; Pedro Paulo M Oliveira; Cristiano Noto; Nicolas Crossley; Philip Mcguire; Quirino Cordeiro; Sintia I O Belangero; Rodrigo A. Bressan; Andrea P. Jackowski; João Ricardo Sato

doi:10.1016/j.jpsychires.2015.09.018

Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis

André Zugman^*, Idaiane Assunção, Gilson Vieira, Ary Gadelha, Thomas P. White, Pedro Paulo M Oliveira, Cristiano Noto, Nicolas Crossley, Philip Mcguire, Quirino Cordeiro, Sintia I O Belangero, Rodrigo A. Bressan, Andrea P. Jackowski, João Ricardo Sato

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy.Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia.

Original language	English
Pages (from-to)	89-96
Number of pages	8
Journal	Journal of psychiatric research
Volume	71
DOIs	https://doi.org/10.1016/j.jpsychires.2015.09.018
Publication status	Published - 1 Dec 2015

Keywords

Graph analysis
Neuroimaging
Schizophrenia
Structural covariance

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10.1016/j.jpsychires.2015.09.018

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Zugman, A., Assunção, I., Vieira, G., Gadelha, A., White, T. P., Oliveira, P. P. M., Noto, C., Crossley, N., Mcguire, P., Cordeiro, Q., Belangero, S. I. O., Bressan, R. A., Jackowski, A. P., & Sato, J. R. (2015). Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis. Journal of psychiatric research, 71, 89-96. https://doi.org/10.1016/j.jpsychires.2015.09.018

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abstract = "Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy.Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia.",

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author = "Andr{\'e} Zugman and Idaiane Assun{\c c}{\~a}o and Gilson Vieira and Ary Gadelha and White, {Thomas P.} and Oliveira, {Pedro Paulo M} and Cristiano Noto and Nicolas Crossley and Philip Mcguire and Quirino Cordeiro and Belangero, {Sintia I O} and Bressan, {Rodrigo A.} and Jackowski, {Andrea P.} and Sato, {Jo{\~a}o Ricardo}",

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Zugman, A, Assunção, I, Vieira, G, Gadelha, A, White, TP, Oliveira, PPM, Noto, C, Crossley, N , Mcguire, P, Cordeiro, Q, Belangero, SIO, Bressan, RA, Jackowski, AP & Sato, JR 2015, 'Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis', Journal of psychiatric research, vol. 71, pp. 89-96. https://doi.org/10.1016/j.jpsychires.2015.09.018

TY - JOUR

T1 - Structural covariance in schizophrenia and first-episode psychosis

T2 - An approach based on graph analysis

AU - Zugman, André

AU - Assunção, Idaiane

AU - Vieira, Gilson

AU - Gadelha, Ary

AU - White, Thomas P.

AU - Oliveira, Pedro Paulo M

AU - Noto, Cristiano

AU - Crossley, Nicolas

AU - Mcguire, Philip

AU - Cordeiro, Quirino

AU - Belangero, Sintia I O

AU - Bressan, Rodrigo A.

AU - Jackowski, Andrea P.

AU - Sato, João Ricardo

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy.Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia.

AB - Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy.Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia.

KW - Graph analysis

KW - Neuroimaging

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KW - Structural covariance

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VL - 71

SP - 89

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JO - Journal of psychiatric research

JF - Journal of psychiatric research

ER -

Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis

Abstract

Keywords

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