Structural magnetic imaging of the hippocampus in early onset schizophrenia.

H Matsumoto; A Simmons; S Williams; R Pipe; R Murray; S Frangou

doi:10.1016/S0006-3223(01)01073-3

Structural magnetic imaging of the hippocampus in early onset schizophrenia.

H Matsumoto, A Simmons, S Williams, R Pipe, R Murray, S Frangou

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Background: Previous literature suggests that hippocampal volume reductions irt schizophrenia may occur either during adolescence or at the point of transition to overt psychosis. The authors rested these hypotheses by examining the hippocampal formation in adolescents with recent onset schizophrenia. Methods: We compared the volumes of the left and right hippocampus, obtained using stereologic method's from magnetic resonance brain images, from 40 adolescents with recent onset schizophrenia to those of nn equal number of matched healthy control subjects. Symptoms were rated using the Positive and Negative Syndrome Si;ale, Results: Compared with control subjects, adolescents with schizophrenia and reduced whole brain volume. After adjusting for brain volume, no group differences were observed in hippocampal volume. Duration of illness was negatively correlated with the volume of the left hippocampus. We found no effect of pregnancy and birth complications or family history of psychosis on hippocampus volumes. There was a negative correlation between severity of psychopathology and hippocampal volumes, which was significant for negative symptoms. Conclusions: Specific hippocampal volume reductions in early onset schizophrenia do not seem to predate the onset of or to occur at the point of transition to psychosis but may develop in adolescence during the early stages of the illness.

Original language	English
Pages (from-to)	824 - 831
Number of pages	8
Journal	Biological psychiatry
Volume	49
Issue number	10
DOIs	https://doi.org/10.1016/S0006-3223(01)01073-3
Publication status	Published - 15 May 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0006-3223(01)01073-3

Cite this

@article{07f8a226fd2d445d8721974adb710f73,

title = "Structural magnetic imaging of the hippocampus in early onset schizophrenia.",

abstract = "Background: Previous literature suggests that hippocampal volume reductions irt schizophrenia may occur either during adolescence or at the point of transition to overt psychosis. The authors rested these hypotheses by examining the hippocampal formation in adolescents with recent onset schizophrenia. Methods: We compared the volumes of the left and right hippocampus, obtained using stereologic method's from magnetic resonance brain images, from 40 adolescents with recent onset schizophrenia to those of nn equal number of matched healthy control subjects. Symptoms were rated using the Positive and Negative Syndrome Si;ale, Results: Compared with control subjects, adolescents with schizophrenia and reduced whole brain volume. After adjusting for brain volume, no group differences were observed in hippocampal volume. Duration of illness was negatively correlated with the volume of the left hippocampus. We found no effect of pregnancy and birth complications or family history of psychosis on hippocampus volumes. There was a negative correlation between severity of psychopathology and hippocampal volumes, which was significant for negative symptoms. Conclusions: Specific hippocampal volume reductions in early onset schizophrenia do not seem to predate the onset of or to occur at the point of transition to psychosis but may develop in adolescence during the early stages of the illness.",

author = "H Matsumoto and A Simmons and S Williams and R Pipe and R Murray and S Frangou",

year = "2001",

month = may,

day = "15",

doi = "10.1016/S0006-3223(01)01073-3",

language = "English",

volume = "49",

pages = "824 -- 831",

journal = "Biological psychiatry",

issn = "1873-2402",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - Structural magnetic imaging of the hippocampus in early onset schizophrenia.

AU - Matsumoto, H

AU - Simmons, A

AU - Williams, S

AU - Pipe, R

AU - Murray, R

AU - Frangou, S

PY - 2001/5/15

Y1 - 2001/5/15

N2 - Background: Previous literature suggests that hippocampal volume reductions irt schizophrenia may occur either during adolescence or at the point of transition to overt psychosis. The authors rested these hypotheses by examining the hippocampal formation in adolescents with recent onset schizophrenia. Methods: We compared the volumes of the left and right hippocampus, obtained using stereologic method's from magnetic resonance brain images, from 40 adolescents with recent onset schizophrenia to those of nn equal number of matched healthy control subjects. Symptoms were rated using the Positive and Negative Syndrome Si;ale, Results: Compared with control subjects, adolescents with schizophrenia and reduced whole brain volume. After adjusting for brain volume, no group differences were observed in hippocampal volume. Duration of illness was negatively correlated with the volume of the left hippocampus. We found no effect of pregnancy and birth complications or family history of psychosis on hippocampus volumes. There was a negative correlation between severity of psychopathology and hippocampal volumes, which was significant for negative symptoms. Conclusions: Specific hippocampal volume reductions in early onset schizophrenia do not seem to predate the onset of or to occur at the point of transition to psychosis but may develop in adolescence during the early stages of the illness.

AB - Background: Previous literature suggests that hippocampal volume reductions irt schizophrenia may occur either during adolescence or at the point of transition to overt psychosis. The authors rested these hypotheses by examining the hippocampal formation in adolescents with recent onset schizophrenia. Methods: We compared the volumes of the left and right hippocampus, obtained using stereologic method's from magnetic resonance brain images, from 40 adolescents with recent onset schizophrenia to those of nn equal number of matched healthy control subjects. Symptoms were rated using the Positive and Negative Syndrome Si;ale, Results: Compared with control subjects, adolescents with schizophrenia and reduced whole brain volume. After adjusting for brain volume, no group differences were observed in hippocampal volume. Duration of illness was negatively correlated with the volume of the left hippocampus. We found no effect of pregnancy and birth complications or family history of psychosis on hippocampus volumes. There was a negative correlation between severity of psychopathology and hippocampal volumes, which was significant for negative symptoms. Conclusions: Specific hippocampal volume reductions in early onset schizophrenia do not seem to predate the onset of or to occur at the point of transition to psychosis but may develop in adolescence during the early stages of the illness.

U2 - 10.1016/S0006-3223(01)01073-3

DO - 10.1016/S0006-3223(01)01073-3

M3 - Article

SN - 1873-2402

VL - 49

SP - 824

EP - 831

JO - Biological psychiatry

JF - Biological psychiatry

IS - 10

ER -

Structural magnetic imaging of the hippocampus in early onset schizophrenia.

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this