Structural mass spectrometry of membrane proteins within their native lipid environments

TY - JOUR

T1 - Structural mass spectrometry of membrane proteins within their native lipid environments

AU - Reading, Eamonn

PY - 2018/4/19

Y1 - 2018/4/19

N2 - Mass spectrometry has emerged as an important structural biology tool for understanding membrane protein structure, function, and dynamics. Generally, structural mass spectrometry of membrane proteins has been performed on purified or reconstituted systems which lack the native lipid membrane and cellular environments. However, there has been progress in the use and adaptations of these methods for probing membrane proteins within increasingly more native contexts. In this Concept article the use and utility of structural mass spectrometry techniques for studying membrane proteins within native environments are highlighted

AB - Mass spectrometry has emerged as an important structural biology tool for understanding membrane protein structure, function, and dynamics. Generally, structural mass spectrometry of membrane proteins has been performed on purified or reconstituted systems which lack the native lipid membrane and cellular environments. However, there has been progress in the use and adaptations of these methods for probing membrane proteins within increasingly more native contexts. In this Concept article the use and utility of structural mass spectrometry techniques for studying membrane proteins within native environments are highlighted

U2 - 10.1002/chem.201801556

DO - 10.1002/chem.201801556

M3 - Article

SN - 0947-6539

JO - CHEMISTRY

JF - CHEMISTRY

ER -