Structural mass spectrometry of membrane proteins within their native lipid environments

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Abstract

Mass spectrometry has emerged as an important structural biology tool for understanding membrane protein structure, function, and dynamics. Generally, structural mass spectrometry of membrane proteins has been performed on purified or reconstituted systems which lack the native lipid membrane and cellular environments. However, there has been progress in the use and adaptations of these methods for probing membrane proteins within increasingly more native contexts. In this Concept article the use and utility of structural mass spectrometry techniques for studying membrane proteins within native environments are highlighted
Original languageEnglish
JournalCHEMISTRY
Early online date19 Apr 2018
DOIs
Publication statusE-pub ahead of print - 19 Apr 2018

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